Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system that
causes demyelination, axonal degeneration and astrogliosis, resulting in progressive …

The blood coagulation protein fibrinogen is deposited in the brain in a wide range of
neurological diseases and traumatic injuries with blood–brain barrier (BBB) disruption …

Combinations of proinflammatory and procoagulant reactions are the unifying principle for a
variety of disorders affecting the cardiovascular system. The factor XII–driven contact system …

Beyond platelets function in hemostasis, there is emerging evidence to suggest that platelets
contribute crucially to inflammation and immune responses. Therefore, considering the …

Background The interaction of coagulation factors has been shown to go beyond their
traditional roles in hemostasis and to affect the development of inflammatory diseases. Key …

The contact system is a potent procoagulant and proinflammatory plasma protease cascade
that is initiated by binding (“contact”)-induced, auto-activation of factor XII zymogen. Formed …

Coagulation factor XII (FXII) deficiency is associated with decreased neutrophil migration,
but the mechanisms remain uncharacterized. Here, we examine how FXII contributes to the …

Factor XII (FXII) is the zymogen of serine protease, factor XIIa (FXIIa). FXIIa enzymatic
activities have been extensively studied and FXIIa inhibition is emerging as a promising …

Inhibiting thrombosis without generating bleeding risks is a major challenge in medicine. A
promising solution may be the inhibition of coagulation factor XII (FXII), because its knock …

Contact activation is the surface-induced conversion of factor XII (FXII) zymogen to the
serine protease FXIIa. Blood-circulating FXII binds to negatively charged surfaces and this …