(1) Background: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) disease (COVID-19) in China at the end of 2019 has caused a large global outbreak …

To date, the application of oxygen-ozone (O2O3) therapy has significantly increased in the
common clinical practice in several pathological conditions. However, beyond the favorable …

Ozone is a highly reactive oxidant molecule consisting of triatomic oxygen atoms. Ozone
therapy can be achieved using ozonated hydrotherapy, ozonated oil, ozone …

(1) Background: Cancer is one of the leading causes of mortality worldwide. Radiotherapy
and chemotherapy attempt to kill tumor cells by different mechanisms mediated by an …

Nuclear factor-E2-related factor 2 (Nrf2) is a key transcription factor known to be involved in
maintaining cell redox balance and signal transduction and plays central role in reducing …

Mitochondria are of great relevance to health, and their dysregulation is associated with
major chronic diseases. Research on mitochondria—156 brand new publications from 2019 …

Medical oxygen-ozone (O2-O3) is a successful therapeutic approach accounting on the
assessed beneficial action of ozone in the range 30–45 μg/ml (expanded range 10–80 …

Introduction The Brazil has one of the largest public health systems in the world and in the
1980's, Traditional, Complementary and Integrative Medicine were introduced. In 2018, the …

Myocardial ischemiasingle bondreperfusion injury (MIRI) is defined as the additional
damage that occurs during the process of restoring blood flow to the heart tissue after …

An increasing amount of reports in the literature is showing that medical ozone (O 3) is used,
with encouraging results, in treating COVID-19 patients, optimizing pain and symptoms …