The highly disagreeable sensation of pain results from an extraordinarily complex and
interactive series of mechanisms integrated at all levels of the neuroaxis, from the periphery …

▪ Abstract The detection of painful stimuli occurs primarily at the peripheral terminals of
specialized sensory neurons called nociceptors. These small-diameter neurons transduce …

TRPA1 is a unique sensor of noxious stimuli and, hence, a potential drug target for
analgesics. Here we show that the antinociceptive effects of spinal and systemic …

1 Capsazepine is a synthetic analogue of the sensory neurone excitotoxin, capsaicin. The
present study shows the capsazepine acts as a competitive antagonist of capsaicin. 2 …

The vanilloid receptor subtype 1 (VR1)/(TRPV1), binding capsaicin, is a non‐selective cation
channel that recently has been shown in human keratinocytes in vitro and in vivo. However …

2. Tachykinins and CGRP in primary afferent neurons 2.1. Synthesis and expression of
tachykinins 2.2. Svnthesis and exnression of CGRP 2.3. Co-localization of tachykinins and …

The ability of capsaicin to excite and subsequently to desensitize a select group of small
sensory neurons has made it a useful tool to study their function. For this reason, application …

Acute nociceptive, inflammatory, and neuropathic pain all depend to some degree on the
peripheral activation of primary sensory afferent neurons. The localized peripheral …

Capsaicin activates a non-specific cation conductance in mammalian sensory neurones. If
capsaicin is applied continuously or repeatedly then there is a progressive decline in …

Capsaicin is a natural protoalkaloid recognized as the main pungent component in hot
peppers (Capsicum annuum L.). The capsaicin receptor is highly expressed in the …