Currently, pyroptosis has received more and more attention because of its association with
innate immunity and disease. The research scope of pyroptosis has expanded with the …

Pyroptosis is closely associated with tumors and inflammatory diseases. By enhancing
pyroptosis, direct and immune-response-triggered deaths of tumor cells are increased …

In the early 2000s, caspase-1, an important molecule that has been shown to be involved in
the regulation of inflammation, cell survival and diseases, was given a new function …

Osteoarthritis (OA) is the most common degenerative joint disease that causes painful
swelling and permanent damage to the joints in the body. The molecular mechanisms of OA …

Abstract The current Coronavirus Disease 2019 (COVID-19) pandemic, caused by the
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is highly contagious …

Cell death is an essential immunological apparatus of host defense, but dysregulation of
mutually inclusive cell deaths poses severe threats during microbial and parasitic infections …

Environmental exposure to crystalline silica (CS) can lead to silicosis. Alveolar
macrophages (AMs) play a crucial role in the pathogenesis of silicosis. Previously, we …

Heart disease is a worldwide health menace. Both intractable primary and secondary
cardiomyopathies contribute to malignant cardiac dysfunction and mortality. One of the key …

Hepatocellular carcinoma (HCC) is the main histologic type of liver cancer. It accounts for
the majority of all diagnoses and deaths due to liver cancer. The induction of tumor cell …

Alzheimer's disease (AD) is a disease characterized by insidious and progressive
neurodegeneration, with clinical syndromes of memory and visuospatial skills damage. The …