Triangle of cytokine storm, central nervous system involvement, and viral infection in COVID-19: the role of sFasL and neuropilin-1

K Saleki, M Banazadeh, NS Miri… - Reviews in the …, 2022 - degruyter.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) is identified as the cause of
coronavirus disease 2019 (COVID-19), and is often linked to extreme inflammatory …

New Perspectives for Antihypertensive Sartans as Components of Co-crystals and Co-amorphous Solids with Improved Properties and Multipurpose Activity

M Turek, E Różycka-Sokołowska… - Molecular …, 2023 - ACS Publications
Sartans (angiotensin II receptor blockers, ARBs), drugs used in the treatment of
hypertension, play a principal role in addressing the global health challenge of …

Kidney organoids reveal redundancy in viral entry pathways during ACE2-dependent SARS-CoV-2 infection

JM Vanslambrouck, JA Neil, R Rudraraju… - Journal of …, 2024 - Am Soc Microbiol
With a high incidence of acute kidney injury among hospitalized COVID-19 patients,
considerable attention has been focussed on whether SARS-CoV-2 specifically targets …

Effect of renin-angiotensin-aldosterone system inhibitors on the rupture risk among hypertensive patients with intracranial aneurysms

P Zhong, Z Lu, Z Li, T Li, Q Lan, J Liu, Z Wang… - …, 2022 - Am Heart Assoc
Background: Mounting experimental evidence supports the concept that the RAAS (renin-
angiotensin-aldosterone system) is involved in the pathogenesis of intracranial aneurysm …

Profiling levels of serum microRNAs and soluble ACE2 in COVID-19 patients

NM Elemam, H Hasswan, H Aljaibeji, NS Sharif-Askari… - Life, 2022 - mdpi.com
Background: The main mechanism of viral entry in COVID-19 infection is through the
angiotensin-converting enzyme 2 (ACE2) receptor present in the lungs. Numerous studies …

Ace2 and innate immunity in the regulation of SARS-CoV-2-induced acute lung injury: A review

L Qu, C Chen, T Yin, Q Fang, Z Hong, R Zhou… - International journal of …, 2021 - mdpi.com
Despite the protracted battle against coronavirus acute respiratory infection (COVID-19) and
the rapid evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Renin–angiotensin system inhibitors positively impact on multiple aging regulatory pathways: Could they be used to protect against human aging?

EMV de Cavanagh, F Inserra, L Ferder - Physiological Reports, 2024 - Wiley Online Library
The renin–angiotensin system (RAS)—a classical blood pressure regulator—largely
contributes to healthy organ development and function. Besides, RAS activation promotes …

[HTML][HTML] Mechanisms for the development of heart failure and improvement of cardiac function by angiotensin-converting enzyme inhibitors

SK Bhullar, AK Shah, NS Dhalla - Scripta Medica, 2022 - scindeks.ceon.rs
Angiotensin-converting enzyme (ACE) inhibitors, which prevent the conversion of
angiotensin I to angiotensin II, are well-known for the treatments of cardiovascular diseases …

Effect of olmesartan and amlodipine on serum angiotensin-(1–7) levels and kidney and vascular function in patients with type 2 diabetes and hypertension

K Kim, JH Moon, CH Ahn, S Lim - Diabetology & Metabolic Syndrome, 2023 - Springer
Background Recent studies suggest that angiotensin-converting enzyme 2 (ACE2) and
angiotensin-(1–7)[Ang-(1–7)] might have beneficial effects on the cardiovascular system. We …

Balancing renal Ang-II/Ang-(1–7) by xanthenone; an ACE2 activator; contributes to the attenuation of Ang-II/p38 MAPK/NF-κB p65 and Bax/caspase-3 pathways in …

AA Azouz, DM Abdel-Rahman… - Toxicology Mechanisms …, 2023 - Taylor & Francis
Despite the great importance of amphotericin B for the management of life-threatening
systemic fungal infections, its nephrotoxic effect restricts its repeated administration. This …