Rho-associated kinases ROCK1 and ROCK2 are serine/threonine kinases that are
downstream targets of the small GTPases RhoA, RhoB, and RhoC. ROCKs are involved in …

Rho-associated kinases ROCK1 and ROCK2 are key regulators of actin cytoskeleton
dynamics downstream of Rho GTPases that participate in the control of important …

Dyslipidemia is associated with endothelial dysfunction. Endothelial dysfunction is the initial
step for atherosclerosis, resulting in cardiovascular complications. It is clinically important to …

Hypertension is one of the common diseases in the elderly. The prevalence of hypertension
markedly increases with advancing age. Both aging and hypertension have a critical role in …

Objective To determine the relationships between flow-mediated vasodilation (FMD) and
cardiovascular risk factors, and to evaluate confounding factors for measurement of FMD in …

Rho kinase (ROCK) is a major downstream effector of the small GTPase RhoA. ROCK
family, consisting of ROCK1 and ROCK2, plays central roles in the organization of actin …

High and low hematocrit (Hct) and hemoglobin (Hb) levels are associated with the risk of
cardiovascular disease. The purpose of this study was to determine the relationships of Hct …

Objective—Nitroglycerine-induced vasodilation has been used as a control test for flow-
mediated vasodilation (FMD) to differentiate endothelium-dependent from endothelium …

In 1986, endothelial function was measured for the first time in patients with atherosclerotic
coronary arteries. Since then, several methods for assessment of endothelial function, such …

Objective—Rho/Rho-kinase (ROCK) pathway in vascular smooth muscle cells (VSMCs)
plays an important role in the pathogenesis of cardiovascular diseases, including pulmonary …