Accumulating evidence suggests that histone hypoacetylation which is partly mediated by
histone deacetylase (HDAC), plays a causative role in the etiology of various clinical …

Although somatic cell nuclear transfer (SCNT) can be used to create transgenic pigs for
human xenotransplantation, low efficiency limits its use. Trichostatin A (TSA) promotes …

Over the last 25 years, cloned animals have been produced by transferring somatic cell
nuclei into enucleated oocytes (SCNT) in more than 20 mammalian species. Among …

Somatic cloning, also known as somatic cell nuclear transfer (SCNT), is a promising
technology which has been expected to rapidly extend the population of elaborately …

Recently, the modification of the epigenetic status of somatic cell nuclear transfer (SCNT)
embryos by treatment with histone deacetylase inhibitors (HDACis) has made it possible to …

The low success rate of animal cloning by somatic cell nuclear transfer (SCNT) is believed to
be associated with aberrant epigenetic nuclear reprogramming. It has been demonstrated …

Recently, a series of genome editing technologies including ZFNs, TALENs, and
CRISPR/Cas9 systems have enabled gene modification in the endogenous target genes of …

Trichostatin A (TSA), a histone deacetylase inhibitor, has been widely used to improve the
cloning efficiency in several species. This brings our attention to investigation of the effects …

SUMMARY OCT4 is a well‐established regulator of pluripotency and nuclear
reprogramming. To determine if improving OCT4 abundance can facilitate oocyte‐mediated …

Animal cloning is of great importance to the production of transgenic and genome-edited
livestock. Especially for multiple gene-editing operations, recloning is one of the most …