Metabolic hormone action in the VTA: Reward-directed behavior and mechanistic insights

CE Geisler, MR Hayes - Physiology & behavior, 2023 - Elsevier
Dysfunctional signaling in midbrain reward circuits perpetuates diseases characterized by
compulsive overconsumption of rewarding substances such as substance abuse, binge …

Animal studies reveal that the ghrelin pathway regulates alcohol-mediated responses

E Jerlhag - Frontiers in Psychiatry, 2023 - frontiersin.org
Alcohol use disorder (AUD) is often described as repeated phases of binge drinking,
compulsive alcohol-taking, craving for alcohol during withdrawal, and drinking with an aim to …

Is there a risk for semaglutide misuse? Focus on the Food and Drug Administration's FDA Adverse Events Reporting System (FAERS) pharmacovigilance dataset

S Chiappini, R Vickers-Smith, D Harris… - Pharmaceuticals, 2023 - mdpi.com
Recent media reports commented about a possible issue of the misuse of antidiabetics
related to molecules promoted as a weight-loss treatment in non-obese people. We …

[HTML][HTML] Insight into the role of the gut-brain axis in alcohol-related responses: emphasis on GLP-1, amylin, and ghrelin

M Tufvesson-Alm, OT Shevchouk, E Jerlhag - Frontiers in Psychiatry, 2023 - frontiersin.org
Alcohol use disorder (AUD) contributes substantially to global morbidity and mortality. Given
the heterogenicity of this brain disease, available pharmacological treatments only display …

Semaglutide and Tirzepatide reduce alcohol consumption in individuals with obesity

F Quddos, Z Hubshman, A Tegge, D Sane, E Marti… - Scientific Reports, 2023 - nature.com
Abstract Alcohol Use Disorder (AUD) contributes significantly to global mortality. GLP-1
(Glucagon-like peptide-1) and GLP-1/GIP (Glucose-dependent Insulinotropic Polypeptide) …

[HTML][HTML] Varenicline and lorcaserin for smoking cessation and weight gain prevention: a randomized clinical trial

RT Hurt, IT Croghan, DR Schroeder, DS Choi… - … : Innovations, Quality & …, 2022 - Elsevier
Objective To evaluate the safety and effectiveness of combination varenicline with lorcaserin
in preventing post-cessation weight gain. Participants and Methods We conducted a …

Mesolimbic exendin-4 attenuates reward salience evoked by neuropeptide Y and ghrelin

AM Brigande, JG Darwich, PJ Currie - Behavioural Brain Research, 2023 - Elsevier
In the present study, we investigated the effects of the glucagon-like peptide-1 (GLP-1)
agonist exendin-4 (Ex-4) on the stimulatory action of neuropeptide Y (NPY) and ghrelin …

Cannabidiol or ketamine for preventing the impact of adolescent early drug initiation on voluntary ethanol consumption in adulthood

MJ Garcia-Fuster, C Colom-Rocha, C Bis-Humbert - 2024 - researchsquare.com
Few studies have previously evaluated the long-term impact of initiating the combined use of
alcohol and cocaine early-in-life during adolescence. Our preclinical study characterized …