Mitochondrial dysfunction and redox imbalance as a diagnostic marker of “free radical diseases”
E Georgieva, D Ivanova, Z Zhelev… - Anticancer …, 2017 - ar.iiarjournals.org
The intracellular redox balance (redox status) is a dynamic system that may change via
many factors. Mitochondria are one of the most important among them. These organelles are …
many factors. Mitochondria are one of the most important among them. These organelles are …
Gender disparity in hepatocellular carcinoma (HCC): multiple underlying mechanisms
B Zheng, YJ Zhu, HY Wang, L Chen - Science China Life Sciences, 2017 - Springer
On the global scale, hepatitis B virus (HBV) infection is the main cause of hepatocellular
carcinoma (HCC) especially in regions of Asia where HBV infection is endemic …
carcinoma (HCC) especially in regions of Asia where HBV infection is endemic …
The therapeutic potential of phosphatase inhibitors
VV Vintonyak, AP Antonchick, D Rauh… - Current opinion in …, 2009 - Elsevier
Protein phosphatases (PPs) constitute a large family of enzymes, which are crucial
modulators of cellular phosphorylation events. Malfunction in PP activity has been …
modulators of cellular phosphorylation events. Malfunction in PP activity has been …
2-Methoxyestradiol synergizes with sorafenib to suppress hepatocellular carcinoma by simultaneously dysregulating hypoxia-inducible factor-1 and-2
L Ma, G Li, H Zhu, X Dong, D Zhao, X Jiang, J Li… - Cancer letters, 2014 - Elsevier
Sorafenib is the approved systemic drug of choice for advanced hepatocellular carcinoma
(HCC), but has demonstrated limited benefits because of drug resistance. 2 …
(HCC), but has demonstrated limited benefits because of drug resistance. 2 …
[HTML][HTML] Cytochrome P450 1A2 metabolizes 17β-estradiol to suppress hepatocellular carcinoma
J Ren, GG Chen, Y Liu, X Su, B Hu, BCS Leung… - PLoS …, 2016 - journals.plos.org
Hepatocellular carcinoma (HCC) occurs more frequently in men than in women. It is
commonly agreed that estrogen plays important roles in suppressing HCC development …
commonly agreed that estrogen plays important roles in suppressing HCC development …
2-Methoxyestradiol synergizes with Erlotinib to suppress hepatocellular carcinoma by disrupting the PLAGL2-EGFR-HIF-1/2α signaling loop
S Zheng, J Ni, Y Li, M Lu, Y Yao, H Guo, M Jiao… - Pharmacological …, 2021 - Elsevier
Erlotinib, an EGFR tyrosine kinase inhibitor has been introduced into cancer chemotherapy.
However, the therapeutic effects of erlotinib in hepatocellular carcinoma (HCC) remain …
However, the therapeutic effects of erlotinib in hepatocellular carcinoma (HCC) remain …
Using small molecules to target protein phosphatases
VV Vintonyak, H Waldmann, D Rauh - Bioorganic & medicinal chemistry, 2011 - Elsevier
The site specific functionalization of phosphate groups with amino acid side chains of
substrate proteins represents one of the most important regulatory mechanisms of biological …
substrate proteins represents one of the most important regulatory mechanisms of biological …
[HTML][HTML] A comprehensive overview of the developments of Cdc25 phosphatase inhibitors
AB Abdelwahab, ER El-Sawy, AG Hanna, D Bagrel… - Molecules, 2022 - mdpi.com
Cdc25 phosphatases have been considered promising targets for anticancer development
due to the correlation of their overexpression with a wide variety of cancers. In the last two …
due to the correlation of their overexpression with a wide variety of cancers. In the last two …
Steroidal anticancer agents: An overview of estradiol-related compounds
R Minorics, I Zupkó - Anti-Cancer Agents in Medicinal …, 2018 - ingentaconnect.com
Research of steroidal compounds as anticancer agents started almost 50 years ago. During
the past decades, several innovative new steroids, like cyproterone, finasteride, estramustin …
the past decades, several innovative new steroids, like cyproterone, finasteride, estramustin …
Clinical and biological significance of never in mitosis gene A-related kinase 6 (NEK6) expression in hepatic cell cancer
X Cao, Y Xia, J Yang, J Jiang, L Chen, R Ni… - Pathology & Oncology …, 2012 - Springer
Nek6 is a cell cycle regulatory gene, which can control cell proliferation and survival. Recent
studies suggested that desregulation of Nek6 expression plays a key role in oncogenesis …
studies suggested that desregulation of Nek6 expression plays a key role in oncogenesis …