Abstract γδ T cells are a unique T cell subpopulation that are rare in secondary lymphoid
organs but enriched in many peripheral tissues, such as the skin, intestines and lungs. By …

IL-17 cytokine family members have diverse biological functions, promoting protective
immunity against many pathogens but also driving inflammatory pathology during infection …

Increased understanding of the biology of interleukin 17 (IL-17) has revealed that this
cytokine is a central player in immunity at the sites most exposed to microorganisms …

Tissue-resident macrophages are a diverse population of cells that perform specialized
functions including sustaining tissue homeostasis and tissue surveillance. Here, we report …

Shortly after the discovery of interleukin 17 (IL-17)-producing CD4+ helper T cells (TH17
cells), it was found that γδ T cells can also secrete large amounts of this pro-inflammatory …

Epithelial and mucosal barriers are critical interfaces physically separating the body from the
outside environment and are the tissues most exposed to microorganisms and potential …

Efficient immune responses against invading pathogens often involve coordination between
cells from both the innate and adaptive immune systems. For multiple decades, it has been …

IL-17-producing γδ T cells express oligoclonal Vγ4+ and Vγ6+ TCRs, mainly develop in the
prenatal thymus, and later persist as long-lived self-renewing cells in all kinds of tissues …

γδ T cells are highly conserved in jawed vertebrates, suggesting an essential role in the
immune system. However, γδ T cell–deficient Tcrd−/− mice display surprisingly mild …

Tissue-resident lymphocytes usually reside in barrier sites and are involved in innate and
adaptive immunity. In recent years, many studies have shown that multiple types of …