Drug discovery in advanced prostate cancer: translating biology into therapy
TA Yap, AD Smith, R Ferraldeschi… - Nature reviews Drug …, 2016 - nature.com
Castration-resistant prostate cancer (CRPC) is associated with a poor prognosis and poses
considerable therapeutic challenges. Recent genetic and technological advances have …
considerable therapeutic challenges. Recent genetic and technological advances have …
[HTML][HTML] Reproduction in a polluted world: implications for wildlife
Environmental pollution is an increasing problem for wildlife globally. Animals are
confronted with many different forms of pollution, including chemicals, light, noise, and heat …
confronted with many different forms of pollution, including chemicals, light, noise, and heat …
[HTML][HTML] Leptin receptor maintains cancer stem-like properties in triple negative breast cancer cells
Q Zheng, L Banaszak, S Fracci, D Basali… - Endocrine-related …, 2013 - erc.bioscientifica.com
Aurora kinases are serine/threonine kinases that play an essential role in cell division. Their
aberrant expression and/or function induce severe mitotic abnormalities, resulting in either …
aberrant expression and/or function induce severe mitotic abnormalities, resulting in either …
Disrupting androgen receptor signaling induces Snail-mediated epithelial–mesenchymal plasticity in prostate cancer
L Miao, L Yang, R Li, DN Rodrigues, M Crespo… - Cancer research, 2017 - AACR
Epithelial-to-mesenchymal plasticity (EMP) has been linked to metastasis, stemness, and
drug resistance. In prostate cancer, EMP has been associated with both suppression and …
drug resistance. In prostate cancer, EMP has been associated with both suppression and …
Systematic identification of microRNAs that impact on proliferation of prostate cancer cells and display changed expression in tumor tissue
A Aakula, P Kohonen, SK Leivonen, R Mäkelä… - European urology, 2016 - Elsevier
Background Systematic approaches to functionally identify key players in microRNA
(miRNA)-target networks regulating prostate cancer (PCa) proliferation are still missing …
(miRNA)-target networks regulating prostate cancer (PCa) proliferation are still missing …
[HTML][HTML] EPI-001 is a selective peroxisome proliferator-activated receptor-gamma modulator with inhibitory effects on androgen receptor expression and activity in …
LJ Brand, ME Olson, P Ravindranathan, H Guo… - Oncotarget, 2015 - ncbi.nlm.nih.gov
The androgen receptor (AR) is a driver of prostate cancer (PCa) cell growth and disease
progression. Therapies for advanced PCa exploit AR dependence by blocking the …
progression. Therapies for advanced PCa exploit AR dependence by blocking the …
[HTML][HTML] Prostate cancer stem-like cells contribute to the development of castration-resistant prostate cancer
Androgen deprivation therapy (ADT) has been the standard care for patients with advanced
prostate cancer (PC) since the 1940s. Although ADT shows clear benefits for many patients …
prostate cancer (PC) since the 1940s. Although ADT shows clear benefits for many patients …
Structural diversity of ligand-binding androgen receptors revealed by microsecond long molecular dynamics simulations and enhanced sampling
M Duan, N Liu, W Zhou, D Li, M Yang… - Journal of Chemical …, 2016 - ACS Publications
Androgen receptor (AR) plays important roles in the development of prostate cancer (PCa).
The antagonistic drugs, which suppress the activity of AR, are widely used in the treatment of …
The antagonistic drugs, which suppress the activity of AR, are widely used in the treatment of …
Molecular dynamics simulations revealed the regulation of ligands to the interactions between androgen receptor and its coactivator
N Liu, W Zhou, Y Guo, J Wang, W Fu… - Journal of chemical …, 2018 - ACS Publications
The androgen receptor (AR) plays important roles in gene expression regulation, sexual
phenotype maintenance, and prostate cancer (PCa) development. The communications …
phenotype maintenance, and prostate cancer (PCa) development. The communications …
Kinase inhibitors in multitargeted cancer therapy
The old-fashioned anticancer approaches, aiming at arresting cancer cell proliferation
interfering with non-specific targets (eg DNA), have been replaced, in the last decades, by …
interfering with non-specific targets (eg DNA), have been replaced, in the last decades, by …