Exosomes regulate the epithelial–mesenchymal transition in cancer

J Jiang, J Li, X Zhou, X Zhao, B Huang, Y Qin - Frontiers in Oncology, 2022 - frontiersin.org
Exosomes are important mediators of intercellular communication and participate in
complex biological processes by transferring a variety of bioactive molecules between cells …

A mechanism for epithelial-mesenchymal heterogeneity in a population of cancer cells

S Tripathi, P Chakraborty, H Levine… - PLoS computational …, 2020 - journals.plos.org
Epithelial-mesenchymal heterogeneity implies that cells within the same tumor can exhibit
different phenotypes—epithelial, mesenchymal, or one or more hybrid epithelial …

Functional annotation of ESR1 gene fusions in estrogen receptor-positive breast cancer

JT Lei, J Shao, J Zhang, M Iglesia, DW Chan, J Cao… - Cell reports, 2018 - cell.com
RNA sequencing (RNA-seq) detects estrogen receptor alpha gene (ESR1) fusion transcripts
in estrogen receptor-positive (ER+) breast cancer, but their role in disease pathogenesis …

miR-665 expression predicts poor survival and promotes tumor metastasis by targeting NR4A3 in breast cancer

XG Zhao, JY Hu, J Tang, W Yi, MY Zhang, R Deng… - Cell death & …, 2019 - nature.com
Cancer metastasis is the main cause of death in breast cancer (BC) patients. Therefore,
prediction and treatment of metastasis is critical for enhancing the survival of BC patients. In …

Downregulation of E-cadherin in pluripotent stem cells triggers partial EMT

CE Aban, A Lombardi, G Neiman, MC Biani… - Scientific reports, 2021 - nature.com
Epithelial to mesenchymal transition (EMT) is a critical cellular process that has been well
characterized during embryonic development and cancer metastasis and it also is …

FNDC3B circular RNA promotes the migration and invasion of gastric cancer cells via the regulation of E‐cadherin and CD44 expression

Y Hong, H Qin, Y Li, Y Zhang, X Zhuang… - Journal of cellular …, 2019 - Wiley Online Library
Circular RNAs (circRNAs) are a new class of RNAs, and many studies have identified
thousands of circRNAs in tumor cells. Fibronectin type III domain‐containing protein 3B …

Breast cancer dormancy: need for clinically relevant models to address current gaps in knowledge

GG Bushnell, AP Deshmukh, P den Hollander… - NPJ breast …, 2021 - nature.com
Breast cancer is the most commonly diagnosed cancer in the USA. Although advances in
treatment over the past several decades have significantly improved the outlook for this …

Role of epithelial-mesenchymal transition in tumor progression

NA Gloushankova, IY Zhitnyak, SN Rubtsova - Biochemistry (Moscow), 2018 - Springer
Epithelial–mesenchymal transition (EMT) is a fundamental process of morphogenesis
whereby epithelial cells acquire the mesenchymal phenotype. Multiple data suggest a …

Circulating tumor cell-derived preclinical models: current status and future perspectives

Z Kahounová, M Pícková, S Drápela, J Bouchal… - Cell Death & …, 2023 - nature.com
Despite the advancements made in the diagnosis and treatment of cancer, the stages
associated with metastasis remain largely incurable and represent the primary cause of …

The role of circulating biomarkers in lung cancer

S Herath, H Sadeghi Rad, P Radfar, R Ladwa… - Frontiers in …, 2022 - frontiersin.org
Lung cancer is the leading cause of cancer morbidity and mortality worldwide and early
diagnosis is crucial for the management and treatment of this disease. Non-invasive means …