The vanilloid receptor TRPV1 (transient receptor potential vanilloid 1) is a cation channel
that serves as a polymodal detector of pain-producing stimuli such as capsaicin, protons …

We evaluated the mechanism of capsaicin-mediated ROS generation in pancreatic cancer
cells. The generation of ROS was about 4–6 fold more as compared to control and as early …

Various cells and inflammatory mediators are involved in the initial pulpal responses to
caries. This review focuses on the cellular, neuronal, and vascular components of pulpal …

Polymodal nociceptors respond to mechanical, thermal and chemical stimuli. Whereas
sensitivities to heat and to the irritant substance capsaicin have recently been linked via the …

BACKGROUND & AIMS: The neuropeptides calcitonin gene-related peptide (CGRP) and
substance P, and calcium channels, which control their release from extrinsic sensory …

Cough accompanied by an increased sensitivity of the cough reflex is the most common
symptom of inflammatory airway disease1, 5. This symptom is also frequently reported in …

Goblet cells are situated in the epithelium of the conducting airways, often with their apical
surfaces protruding into the lumen, a location which fits them for a rapid response to inhaled …

Purinergic signalling is involved in a number of physiological and pathophysiological
activities in the lower urinary tract. In the bladder of laboratory animals there is …

Some synthetic agonists of the VR1 vanilloid (capsaicin) receptor also inhibit the facilitated
transport into cells of the endogenous cannabinoid anandamide (arachidonoylethanolamide …

The nose provides defensive and homeostatic functions requiring rapid responses to
physical and chemical stimuli. As a result, it is armed with a complex nervous system that …