Vanilloid receptor subtype 1, VR1, is an ion channel that serves as a polymodal detector of
pain-producing chemicals such as capsaicin and protons in primary afferent neurons. Here …

Capsaicin activates a non-specific cation conductance in mammalian sensory neurones. If
capsaicin is applied continuously or repeatedly then there is a progressive decline in …

Medical management of obesity represents a large unmet clinical need. Animal experiments
suggest a therapeutic potential for dietary capsaicin, the pungent ingredient in hot chili …

The maintenance of gastric mucosal integrity depends on the rapid alarm of protective
mechanisms in the face of pending injury. Afferent neurons of extrinsic origin constitute an …

Many known painkillers are not always effective in the therapy of chronic neuropathic pain
manifested by hyperalgesia and tactile allodynia. The mechanisms underlying neuropathic …

Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide) is a major pungent ingredient of the
Capsicum fruits such as hot green and red peppers. Besides its use as a food additive in …

The preprotachykinin-A gene-derived peptides substance P and neurokinin (NK) A are
expressed in distinct neural pathways of the mammalian gut. When released from intrinsic …

Background and aims: The role of sensory neurones in colitis was studied by chemical
denervation of primary sensory neurones as well as antagonism of the vanilloid receptor-1 …

Nasal obstruction can be monitored objectively by measurement of nasal airflow, as
evaluated by nasal peak flow, or as airways resistance/conductance as evaluated by …

Neuropathic pain, caused by a lesion or disease affecting the somatosensory system, affects
between 3 and 17% of the general population. The treatment of neuropathic pain is …