Purine nucleoside phosphorylase (PNP) deficiency is a rare inherited disease accounting
for approximately 4% of patients with severe combined immunodeficiency. Thirty-three …

Purine nucleotide degradation refers to a regulated series of reactions by which human
purine ribonucleotides and deoxyribonucleotides are degraded to uric acid in humans. Two …

The ternary complex of purine nucleoside phosphorylase from E. coli with formycin B and a
sulphate or phosphate ion crystallized in the hexagonal space group P6122 with unit cell …

A number of inborn errors of purine metabolism have been associated with
immunodeficiency diseases. From studies to the possible mechanism (s) leading to the …

Calf spleen purine nucleoside phosphorylase was purified to homogeneity and its amino
acid sequence was determined. The complex of the enzyme with an N (7)-acycloguanosine …

It has long been appreciated that purine nucleoside phosphorylase (PNP; purine
nucleoside: orthophosphate ribosyltransferase, EC 2.4. 2.1) may play a role in cancer …

Deazapurine ribonucleosides constitute a new class of noncleavable purine nucleoside
phosphorylase inhibitors that have at least 30-fold greater affinity for the enzyme than the …

The possibility that patients with primary immunodeficiency diseases, such as primary
hypogammaglobulinaemia, are especially susceptible to giardiasis is discussed. Although …

Deficiency of purine nucleoside phosphorylase (PNP) was detected in a 3-yr-oId boy who
was admitted for investigation of a behavior disorder and spastic diplegia. The urinary …

The courses of six patients with adenosine deaminase (ADA) and two with purine
nucleoside phosphorylase (PNP) deficiencies were evaluated before and after therapy. The …