Tricyclic antidepressants and serotonin noradrenaline reuptake inhibitors are used to treat
chronic pain, such as neuropathic pain. Why antidepressants are effective for treatment of …

Neuropathic pain arises as a consequence of a lesion or disease affecting the
somatosensory system. It is generally chronic and challenging to treat. The recommended …

Comorbid depression and chronic pain are highly prevalent in individuals suffering from
physical illness. Here, we critically examine the possibility that inflammation is the common …

Background and objective Low back pain (LBP) is one of the most common chronic pain
conditions. This paper reviews the available literature on the role of neuropathic …

Abstract The K+-Cl− cotransporter KCC2 is responsible for maintaining low Cl−
concentration in neurons of the central nervous system (CNS), which is essential for …

El dolor es la principal causa de consulta médica. El costo económico del dolor es brutal.
Tan solo en Estados Unidos, en el 2010, se estiman costos totales entre 560y 635 billones …

Low back pain is one of the four most common disorders in all regions, and the greatest
contributor to disability worldwide, adding 10.7% of total years lost due to this health state …

Background Burning mouth syndrome is a chronic idiopathic intractable intraoral
dysaesthesia that remains a challenge to clinicians due to its poorly understood …

People with rheumatoid arthritis (RA) identify pain as their most important symptom, one that
often persists despite optimal control of inflammatory disease. RA pain arises from multiple …

Background: Emotional disorders are common comorbid affectations that exacerbate the
severity and persistence of chronic pain. Specifically, depressive symptoms can lead to an …