Disturbed cholesterol homeostasis plays critical roles in the development of multiple
diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and …

Foam cells play a vital role in the initiation and development of atherosclerosis. This review
aims to summarize the novel insights into the origins, consequences, and molecular …

Trait-associated genetic variants affect complex phenotypes primarily via regulatory
mechanisms on the transcriptome. To investigate the genetics of gene expression, we …

While many disease-associated variants have been identified through genome-wide
association studies, their downstream molecular consequences remain unclear. To identify …

The remarkable plasticity and plethora of biological functions performed by macrophages
have enticed scientists to study these cells in relation to atherosclerosis for> 50 years, and …

Hypercholesterolaemia leads to cholesterol accumulation in macrophages and other
immune cells, which promotes inflammatory responses, including augmentation of Toll-like …

Rationale: Monocyte infiltration into the subintimal space and its intracellular lipid
accumulation are the most prominent features of atherosclerosis. To understand the …

High-density lipoprotein (HDL) has been proposed to have several antiatherosclerotic
properties, including the ability to mediate macrophage cholesterol efflux, antioxidant …

Background High-density lipoprotein (HDL) may provide cardiovascular protection by
promoting reverse cholesterol transport from macrophages. We hypothesized that the …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …