The S100 proteins, a family of calcium-binding cytosolic proteins, have a broad range of
intracellular and extracellular functions through regulating calcium balance, cell apoptosis …

As one of the most serious threats to human being, cancer is hard to be treated when
metastasis happens. What's worse, there are few identified targets of metastasis for drug …

High recurrence and metastasis of triple-negative breast cancer (TNBC) after operation is a
leading cause of breast cancer related death. The pre-metastatic niche (PMN) is an …

Most tumor cells undergo apoptosis in circulation and at the metastatic organ sites due to
host immune surveillance and a hostile microenvironment. It remains to be elucidated …

Liver metastases develop in more than half of the patients with colorectal cancer (CRC) and
are associated with a poor prognosis. The factors influencing liver metastasis of CRC are …

Exosomes are increasingly recognized as important mediators of cell–cell communication in
cancer progression through the horizontal transfer of RNAs and proteins to neighboring or …

Vascular walls change their dimension and mechanical properties in response to injury such
as balloon angioplasty and endovascular stent implantation. Placement of bare metal stents …

Calmodulin (CaM) is a ubiquitous Ca 2+ receptor protein mediating a large number of
signaling processes in all eukaryotic cells. CaM plays a central role in regulating a myriad of …

S100 proteins are widely expressed small molecular EF-hand calcium-binding proteins of
vertebrates, which are involved in numerous cellular processes, such as Ca2+ homeostasis …

Purpose: Oncogenic mutations in the KRAS/PI3K/AKT pathway are one of the most frequent
alterations in cancer. Although PI3K or AKT inhibitors show promising results in clinical …