Common cytokine receptor γ-chain (γc) family cytokines have crucial roles in the
development, proliferation, survival and differentiation of multiple cell lineages of both the …

The adaptive immune response meets the needs of the organism to generate effector cells
capable of controlling pathogens but also leads to production of memory cells, which …

Immunological memory is a cardinal feature of adaptive immunity. We are now beginning to
elucidate the mechanisms that govern the formation of memory T cells and their ability to …

After infection, most antigen-specific memory T cells reside in nonlymphoid tissues. Tissue-
specific programming during priming leads to directed migration of T cells to the appropriate …

ZEB2 is a multi-zinc-finger transcription factor known to play a significant role in early
neurogenesis and in epithelial-mesenchymal transition–dependent tumor metastasis …

CD8+ T cells (also called cytotoxic T lymphocytes) play a major role in protective immunity
against many infectious pathogens and can eradicate malignant cells. The path from naive …

During viral infection, effector CD8 T cells contract to form a population of protective memory
cells that is maintained by IL-7 and IL-15. The mechanisms that control effector cell death …

The adaptive immune system has evolved a unique capacity to remember a pathogen
through the generation of memory T cells, which rapidly protect the host in the event of …

Viral infections cause an immunological disequilibrium that provokes CD8 T cell responses.
These cells play critical roles in purging acute infections, limiting persistent infections, and …

It has become apparent that T cells require growth signals to maintain function and viability
necessary to maintain proper immune homeostasis. One means by which cell extrinsic …