Goblet cells and the mucus they secrete serve as an important barrier, preventing pathogens
from invading the mucosa to cause intestinal inflammation. The perspective regarding goblet …

1Department of Pathology and Microbiology, University of Bristol, Homoeopathic Hospital
Site, Cotham, Bristol BS6 6JU, UK; 2University of Glasgow Department of Surgery, Queen …

Inflammatory bowel disease (IBD) typically manifests as either ulcerative colitis (UC) or
Crohn's disease (CD). Systematic identification of susceptibility genes for IBD has thus far …

Background & Aims Treatment of inflammatory bowel disease would benefit from specific
targeting of therapeutics to the intestine. We developed a strategy for localized delivery of …

Paradoxically, the pro-inflammatory cytokine IL-6 and the anti-inflammatory cytokine IL-10
both activate STAT3, yet generate nearly opposing cellular responses. Here, we show that …

Background: Post‐infectious irritable bowel syndrome is a common clinical phenomenon of
uncertain aetiology. Aim: To test the association between intestinal permeability and irritable …

Background & Aims: Both infliximab (chimeric anti-tumor necrosis factor [TNF]-α antibody)
and etanercept (p75 TNF-α receptor/immunoglobulin G fusion protein) are effective against …

OBJECTIVE: Cytokines play a key role in the regulation of the immune response. The
maximal capacity of cytokine production varies among individuals and correlates with the …

Inflammatory bowel diseases (IBD) such as Crohn's disease (CD) or ulcerative colitis are
chronic intestinal disorders, which are on the increase in “Westernised” countries. IBD can …

Background and aims: Inflammation may play a role in the pathogenesis of irritable bowel
syndrome in some individuals, such as in those who develop symptoms following a …