The renin-angiotensin-aldosterone system and the kidney: effects on kidney disease

UC Brewster, MA Perazella - The American journal of medicine, 2004 - Elsevier
The renin-angiotensin-aldosterone system regulates renal vasomotor activity, maintains
optimal salt and water homeostasis, and controls tissue growth in the kidney. However …

ACE2 and ACE: structure-based insights into mechanism, regulation and receptor recognition by SARS-CoV

L Lubbe, GE Cozier, D Oosthuizen, KR Acharya… - Clinical …, 2020 - portlandpress.com
Angiotensin converting enzyme (ACE) is well-known for its role in blood pressure regulation
via the renin–angiotensin aldosterone system (RAAS) but also functions in fertility, immunity …

Serial triggering of many T-cell receptors by a few peptide–MHC complexes

S Valitutti, S Müller, M Cella, E Padovan… - Nature, 1995 - nature.com
T LYMPHOCYTES can recognize and be activated by a very small number of complexes of
peptide with major histocompatibility complex (MHC) molecules displayed on the surface of …

Male–female differences in fertility and blood pressure in ACE-deficient mice

JH Krege, SWM John, LL Langenbach, JB Hodgin… - Nature, 1995 - nature.com
Abstract ANGIOTENSIN-CONVERTING enzyme (ACE) is a dipeptidyl carboxy-peptidase that
generates the vasoconstricting peptide angiotensin II and inactivates the vasodilating …

Paracrine regulation of the renal microcirculation

LG Navar, EW Inscho, SA Majid, JD Imig… - Physiological …, 1996 - journals.physiology.org
There has been an explosive growth of interest in the multiple interacting paracrine systems
that influence renal microvascular function. This review first discusses the membrane …

Angiotensin II and the fibroproliferative response to acute lung injury

RP Marshall, P Gohlke, RC Chambers… - … of Physiology-Lung …, 2004 - journals.physiology.org
Angiotensin II (ANG II), generated by activation of local renin-angiotensin systems, is
believed to play an important role in tissue repair and remodeling, in part via transforming …

Targeting drug delivery in the vascular system: Focus on endothelium

PM Glassman, JW Myerson, LT Ferguson… - Advanced drug delivery …, 2020 - Elsevier
The bloodstream is the main transporting pathway for drug delivery systems (DDS) from the
site of administration to the intended site of action. In many cases, components of the …

Regulation of intrarenal angiotensin II in hypertension

LG Navar, LM Harrison-Bernard, A Nishiyama… - …, 2002 - Am Heart Assoc
Intrarenal angiotensin II (Ang II) is regulated by several complex processes involving
formation from both systemically delivered and intrarenally formed substrate, as well as …

Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase

SM Keyse, EA Emslie - Nature, 1992 - nature.com
REACTIVE oxygen species have been implicated both in the ageing process and in
degenerative diseases, including arthritis and cancer1, 2. Bacteria adapt to the lethal effects …

Angiotensin-(1-7) dilates canine coronary arteries through kinins and nitric oxide

KB Brosnihan, P Li, CM Ferrario - Hypertension, 1996 - Am Heart Assoc
Abstract Angiotensin-(1-7)[Ang-(1-7)] was recently recognized to have novel biological
functions that are distinct from those of Ang II. In these studies, we determined the vasoactive …