Theranostic Activity of Ceria-Based Nanoparticles toward Parental and Metastatic Melanoma: 2D vs 3D Models

K K. Johnson, C Kopecky, P Koshy, Y Liu… - ACS Biomaterials …, 2023 - ACS Publications
The time interval between the diagnosis of tumor in a patient and the initiation of treatment
plays a key role in determining the survival rates. Consequently, theranostics, which is a …

Precision nephrotoxicity testing using 3D in vitro models

P Yu, H Zhu, CC Bosholm, D Beiner, Z Duan… - Cell & Bioscience, 2023 - Springer
Nephrotoxicity is a significant concern during the development of new drugs or when
assessing the safety of chemicals in consumer products. Traditional methods for testing …

Human Brain Organoids in Migraine Research: Pathogenesis and Drug Development

P Gazerani - International Journal of Molecular Sciences, 2023 - mdpi.com
Human organoids are small, self-organized, three-dimensional (3D) tissue cultures that
have started to revolutionize medical science in terms of understanding disease, testing …

3d cell culture models in covid-19 times: A review of 3D technologies to understand and accelerate therapeutic drug discovery

GT de Dios-Figueroa, JR Aguilera-Marquez… - Biomedicines, 2021 - mdpi.com
In the last decades, emerging viruses have become a worldwide concern. The fast and
extensive spread of the disease caused by SARS-CoV-2 (COVID-19) has impacted the …

[HTML][HTML] Organ-on-chip technology: Opportunities and challenges

SK Srivastava, GW Foo, N Aggarwal, MW Chang - Biotechnology Notes, 2024 - Elsevier
Abstract Organ-on-chip (OOC) technology is an innovative approach that reproduces human
organ structures and functions on microfluidic platforms, offering detailed insights into …

[HTML][HTML] A review on alternative methods to experimental animals in biological testing: recent advancement and current strategies

A Husain, DU Meenakshi, A Ahmad… - Journal of Pharmacy …, 2023 - journals.lww.com
With an increase in the progression of research and development in the medical field, the
experimental use of animals for the efficacy and safety testing of pharmaceuticals is on rise …

Pro-Apoptotic Activity and Cell Cycle Arrest of Caulerpa sertularioides against SKLU-1 Cancer Cell in 2D and 3D Cultures

R Agena, ADJ Cortés-Sánchez, H Hernández-Sánchez… - Molecules, 2023 - mdpi.com
Cancer is a disease with the highest mortality and morbidity rate worldwide. First-line drugs
induce several side effects that drastically reduce the quality of life of people with this …

Droplet contact-based spheroid transfer technique as a multi-step assay tool for spheroid arrays

H Kim, H Roh, H Kim, JK Park - Lab on a Chip, 2021 - pubs.rsc.org
Hanging drop plates and low-attachment well plates are suitable for a high throughput
screening model of a spheroid, because each drop (or well) contains a single spheroid and …

An adverse outcomes approach to study the effects of SARS-CoV-2 in 3D organoid models

A Basu, A Pamreddy, P Singh, K Sharma - Journal of Molecular Biology, 2022 - Elsevier
The novel SARS-CoV-2 virus outbreak is the major cause of a respiratory disease known as
COVID-19. It has caused a global pandemic and has resulted in mortality in millions. The …

3D cell cultures, as a surrogate for animal models, enhance the diagnostic value of preclinical in vitro investigations by adding information on the tumour …

SI Bär, B Biersack, R Schobert - Investigational New Drugs, 2022 - Springer
Anchorage-independent 3D-cultures of multicellular tumour spheroids (MCTS) and in vitro
microtumours of cancer cells can provide upfront information on the effects of anticancer …