Hardeveld F, Spijker J, De Graaf R, Nolen WA, Beekman ATF. Prevalence and predictors of
recurrence of major depressive disorder in the adult population. Objective: Knowledge of the …

Lipid peroxidation (LPO) product accumulation in human tissues is a major cause of tissular
and cellular dysfunction that plays a major role in ageing and most age-related and …

Background The UK Prospective Diabetes Study showed that metformin decreases mortality
compared to diet alone in overweight patients with type 2 diabetes mellitus. Since then, it …

The insulin resistance syndrome (syndrome X, metabolic syndrome) has become the major
health problem of our times. Associated obesity, dyslipidemia, atherosclerosis, hypertension …

Background and Purpose Recent clinical trials report that metformin, an activator of AMP‐
activated protein kinase (AMPK) used to treat type 2 diabetes, significantly reduces the risk …

Background In type 2 diabetes mellitus there is a progressive loss of beta‐cell function. One
new approach yielding promising results is the use of the orally active dipeptidyl peptidase …

Today, we know that a primary metabolic action of insulin is to facilitate the postprandial
disposition of glucose via its actions on three key target tissues: suppression of glucose …

Background Metformin is an anti‐hyperglycaemic agent used for the treatment of type 2
diabetes mellitus. Type 2 diabetes may present long‐term complications: micro‐(retinopathy …

The sulphonylureas act by triggering insulin release from the pancreatic β cell. A specific site
on the adenosine triphosphate (ATP)-sensitive potassium channels is occupied by …

Methods I identified references to remission and relapse of depression during the writing up
of the Australian national mental health survey. References to long term prognosis came …