The developing utility of zebrafish models of neurological and neuropsychiatric disorders: A critical review
BD Fontana, NJ Mezzomo, AV Kalueff… - Experimental …, 2018 - Elsevier
Zebrafish (Danio rerio) have become a powerful tool in neuroscience research due to their
genetic tractability, molecular/physiological conservation, small body size, ease of …
genetic tractability, molecular/physiological conservation, small body size, ease of …
Zebrafish models in neuropsychopharmacology and CNS drug discovery
Despite the high prevalence of neuropsychiatric disorders, their aetiology and molecular
mechanisms remain poorly understood. The zebrafish (Danio rerio) is increasingly utilized …
mechanisms remain poorly understood. The zebrafish (Danio rerio) is increasingly utilized …
[HTML][HTML] Ciliary beating compartmentalizes cerebrospinal fluid flow in the brain and regulates ventricular development
Motile cilia are miniature, propeller-like extensions, emanating from many cell types across
the body. Their coordinated beating generates a directional fluid flow, which is essential for …
the body. Their coordinated beating generates a directional fluid flow, which is essential for …
Neurodevelopmental abnormalities and congenital heart disease: insights into altered brain maturation
PD Morton, N Ishibashi, RA Jonas - Circulation research, 2017 - Am Heart Assoc
In the past 2 decades, it has become evident that individuals born with congenital heart
disease (CHD) are at risk of developing life-long neurological deficits. Multifactorial risk …
disease (CHD) are at risk of developing life-long neurological deficits. Multifactorial risk …
Glia-neuron interactions underlie state transitions to generalized seizures
C Diaz Verdugo, S Myren-Svelstad, E Aydin… - Nature …, 2019 - nature.com
Brain activity and connectivity alter drastically during epileptic seizures. The brain networks
shift from a balanced resting state to a hyperactive and hypersynchronous state. It is …
shift from a balanced resting state to a hyperactive and hypersynchronous state. It is …
Past, present and future of zebrafish in epilepsy research
E Yaksi, A Jamali, C Diaz Verdugo… - The FEBS …, 2021 - Wiley Online Library
Animal models contribute greatly to our understanding of brain development and function as
well as its dysfunction in neurological diseases. Epilepsy research is a very good example of …
well as its dysfunction in neurological diseases. Epilepsy research is a very good example of …
Glucocerebrosidase 1 deficient Danio rerio mirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding …
M Keatinge, H Bui, A Menke, YC Chen… - Human molecular …, 2015 - academic.oup.com
Autosomal recessively inherited glucocerebrosidase 1 (GBA1) mutations cause the
lysosomal storage disorder Gaucher's disease (GD). Heterozygous GBA1 mutations …
lysosomal storage disorder Gaucher's disease (GD). Heterozygous GBA1 mutations …
Zebrafish as an innovative tool for epilepsy modeling: state of the art and potential future directions
This article discusses the potential of Zebrafish (ZF)(Danio Rerio), as a model for epilepsy
research. Epilepsy is a neurological disorder affecting both children and adults, and many …
research. Epilepsy is a neurological disorder affecting both children and adults, and many …
Loss of glutamate transporter eaat2a leads to aberrant neuronal excitability, recurrent epileptic seizures, and basal hypoactivity
AL Hotz, A Jamali, NN Rieser, S Niklaus, E Aydin… - Glia, 2022 - Wiley Online Library
Astroglial excitatory amino acid transporter 2 (EAAT2, GLT‐1, and SLC1A2) regulates the
duration and extent of neuronal excitation by removing glutamate from the synaptic cleft …
duration and extent of neuronal excitation by removing glutamate from the synaptic cleft …
Breeding zebrafish: a review of different methods and a discussion on standardization
In recent years, a rapidly increasing number of scientific papers have been published that
utilize zebrafish (Danio rerio) as an alternative model organism in the study of a wide range …
utilize zebrafish (Danio rerio) as an alternative model organism in the study of a wide range …