Abstract Purpose of Review Thiazolidinediones (TZDs) are the only pharmacologic agents
that specifically treat insulin resistance. The beneficial effects of TZDs on the cardiovascular …

Heart failure (HF) is growing to a modern epidemic and despite advances in therapy, it still
carries an ominous prognosis and a significant socioeconomic burden. 1 Many novel agents …

Chronic inflammation and oxidative stress are common and co-substantial pathological
processes accompanying and contributing to cancers. Numerous epidemiological studies …

Metabolic syndrome (MetS) is a common feature in obesity, comprising a cluster of
abnormalities including abdominal fat accumulation, hyperglycemia, hyperinsulinemia …

Background Peroxisome proliferator-activated receptors (PPARs) are a class of ligand-
activated nuclear transcription factors, members of the type nuclear receptor superfamily …

Type 2 diabetes mellitus (T2DM) is a common chronic metabolic condition. Before receiving
this diagnosis, persons typically have a long period of prediabetes. There is good evidence …

Background: Diabetes is a multifactorial disease and a major cause for many microvascular
and macrovascular complications. The disease will ultimately lead to high rate mortality if it …

Autism spectrum disorder (ASD) is a neurodevelopmental disorder that is characterized by a
deficit in social interactions and communication with repetitive and restrictive behavior. No …

Peroxisome proliferator-activated receptor-γ (PPAR-γ) partial agonists or antagonists, also
termed as selective PPAR-γ modulators, are more beneficial than full agonists because they …

With an estimated 422 million affected patients worldwide in 2016, type 2 diabetes (T2D)
has reached pandemic proportions and represents a major unmet medical need. T2D is a …