Synucleinopathies, including Parkinson's disease (PD), dementia with Lewy Bodies (DLB),
and multiple system atrophy (MSA), are characterized by the misfolding and subsequent …

Most of the cell's chemical reactions and structural components are facilitated by proteins.
But proteins are highly dynamic molecules, where numerous modifications or changes in the …

Plant protein fibrils have recently attracted considerable attention as delivery vehicles for
hydrophobic bioactive compounds. In this work, ultrasound treatment was applied to …

Peptides and their mimetics are increasingly recognised as drug-like molecules, particularly
for intracellular protein-protein interactions too large for inhibition by small molecules, and …

Introduction The most prevalent biological macromolecules in living systems are proteins,
the building block of life, extremely dynamic in structure and functions. Due to several …

Microbe (including bacteria, fungi, and virus) infection in brains is associated with amyloid
fibril deposit and neurodegeneration. Increasing findings suggest that amyloid proteins, like …

The accumulation of pathogenic protein oligomers and aggregates is associated with
several devastating amyloid diseases. As protein aggregation is a multi-step nucleation …

Before the controversial approval of humanized monoclonal antibody lecanemab, which
binds to the soluble amyloid‐β protofibrils, all the treatments available earlier, for …

Despite the ubiquitous absorption of mid-infrared (IR) radiation by virtually all molecules that
belong to the major biomolecules groups (proteins, lipids, carbohydrates, nucleic acids), the …

Stability of high-concentration protein formulations is considered a major challenge in
current biopharmaceutical development. In this work, we introduce laser-based mid-infrared …