Maturation is the last phase of heart development that prepares the organ for strong,
efficient, and persistent pumping throughout the mammal's lifespan. This process is …

Gap junctions consist of arrays of intercellular channels that enable adjacent cells to
communicate both electrically and metabolically. Gap junctions have a wide diversity of …

Connexins are a family of transmembrane proteins that play a key role in cardiac physiology.
Gap junctional channels put into contact the cytoplasms of connected cardiomyocytes …

Over 35 years ago the cell biology community was introduced to connexins as the subunit
employed to assemble semicrystalline clusters of intercellular channels that had been well …

Cardiac connexin-43 (Cx43) creates gap junction channels (GJCs) at intercellular contacts
and hemi-channels (HCs) at the peri-junctional plasma membrane and sarcolemmal …

Homoeostasis depends on the close connection and intimate molecular exchange between
extracellular, intracellular and intercellular networks. Intercellular communication is largely …

The 21-member connexin gene family exhibits distinct tissue expression patterns that can
cause a diverse array of over 30 inherited connexin-linked diseases ranging from deafness …

In myelinating Schwann cells, connection between myelin layers is mediated by gap
junction channels (GJCs) formed by docked connexin 32 (Cx32) hemichannels (HCs) …

Purpose In recent decades, the occurrence of heart failure with preserved ejection fraction
(HFpEF) has outweighed that of heart failure with reduced ejection fraction by degrees, but …

Abstract Aims Brugada syndrome (BrS) is characterized by a unique electrocardiogram
(ECG) pattern and life-threatening arrhythmias. However, the Type 1 Brugada ECG pattern …