Diabetes mellitus (DM) is considered as a main challenge in both developing and
developed countries, as lifestyle has changed and its management seems to be vital. Type I …

Diabetes prevalence continues to climb with the aging population. Type 2 diabetes (T2D),
which constitutes most cases, is metabolically acquired. Diabetic peripheral neuropathy …

Neuropathy will afflict over half of the estimated 460 million people worldwide who have
diabetes, 303 of whom approximately onethird will also develop neuropathic pain. 2 The …

In the cornea, resident immune cells are in close proximity to sensory nerves, consistent with
their important roles in the maintenance of nerves in both homeostasis and inflammation …

The AMPK/PGC-1α pathway-mediated mitochondrial dysfunction has been supposed to
play a crucial role in pathogenesis of diabetic peripheral neuropathy (DPN). The present …

Inflammation and oxidative stress contribute to the progression of acute lung injury (ALI).
Galectin-1 (Gal-1) has important anti-inflammatory properties in renal ischemia-reperfusion …

Introduction: Metformin is currently first line therapy for type 2 diabetes (T2D). The
mechanism of action of metformin involves activation of AMP-activated protein kinase …

Neurodegenerative disorders are accompanied by neuronal degeneration and glial
dysfunction, resulting in cognitive, psychomotor, and behavioral impairment. Multiple factors …

Mining of integrated public transcriptomic and ChIP-Seq (cistromic) datasets can illuminate
functions of mammalian cellular signaling pathways not yet explored in the research …

As a major late complication of diabetes, diabetic peripheral neuropathy (DPN) is the
primary reason for amputation. Nevertheless, there are no wonder drugs available …