Atrial fibrillation (AF) is the most common sustained clinical arrhythmia and is associated
with significant morbidity, mostly secondary to heart failure and stroke, and an estimated two …

Atrial fibrillation (AF) is the most common cardiac rhythm abnormality and represents a major
burden, both to patients and to health-care systems. In recent years, increasing evidence …

Objectives: We postulated a change of angiotensin II receptor subtype expression in patients
with lone atrial fibrillation (AF) and AF with underlying mitral valve disease (MVD) both …

Objective: Although the incidence of atrial fibrillation (AF) increases with age, the cellular
electrophysiological changes that render the atria of aged individuals more susceptible to …

Background—Currently available antiarrhythmic drugs are only moderately effective against
atrial fibrillation (AF) and may cause ventricular proarrhythmia. AVE0118 is a blocker of …

Cardiac electrophysiology is a complex system established by a plethora of inward and
outward ion currents in cardiomyocytes generating and conducting electrical signals in the …

Objective.–Rapid stimulation causes electrical remodeling in the intact atrium, with
shortening of action potential duration (APD), down-regulation of L-type Ca2+ currents (ICa …

Background and aims An inverse relationship between lipid levels and atrial fibrillation (AF)
has been suggested, but whether the association is upheld for all age groups remains …

There is a clear unmet medical need for new pharmacologic therapies for the treatment of
atrial fibrillation (AF) with improved efficacy and safety. This article reviews the development …

Objectives: M cells have been described in many mammalian species. They are thought to
be relevant for the genesis of long QT intervals, afterdepolarizations and for dispersion in …