Ectopic activity in cardiac muscle within pulmonary veins (PVs) is associated with the onset
and the maintenance of atrial fibrillation in humans. The mechanism underlying this ectopic …

The complex pathophysiology of human arrhythmias has proven difficult to model. Direct
correlations between the traditional arrhythmia mechanisms, including abnormal excitability …

Background Substantial focus has been placed on atrial fibrillation (AF) treatment and
associated stroke prevention rather than preventing AF itself. We employed Mendelian …

Background Atrial fibrillation (AF) is one of the most common cardiac arrhythmias. In some
patients, the disease is inheritable; however, hereditary aspects of AF remain not fully …

Aims Structural alterations during atrial fibrillation (AF) not only lead to electrical dissociation
within the epicardial layer, but also between the epicardial layer and the endocardial bundle …

Background and purpose: Atrial fibrillation (AF) is the most common electrical cardiac
disorder in clinical practice. The major trigger for AF is focal ectopic activity of unknown …

Atrial arrhythmias are a common problem in cardiological practice. Despite the availability of
several antiarrhythmic drugs, there is a medical need for safer and more efficient …

Mechanical stimuli delivered to the precordium can, if strong enough and timed at the
beginning of the T-wave, induce ventricular premature beats or runs of ventricular …

Objective: To assess the contribution of the Na, K pump current (I p) to the action potential
duration (APD) and effective refractory period (ERP) in human atrial cells, and to investigate …

Currently available antiarrhythmic drugs for the management of AF are not sufficiently
effective and are burdened with cardiac and extracardiac side effects that may offset their …