Breast cancer has become a serious threat to women's health. Cancer progression is mainly
derived from resistance to apoptosis induced by procedures or therapies. Therefore, new …

With the significant increase of patients suffering from different types of cancer, it is evident
that prompt measures in the development of novel and effective agents need to be taken …

Tumor associated macrophages (TAM) enhance the aggressiveness of breast cancer via
promoting cancer cell growth, metastasis, and suppression of the patient's immune system …

Significance: After approximatelty three decades of research, two Mn (III) porphyrins (MnPs),
MnTE-2-PyP5+ (BMX-010, AEOL10113) and MnTnBuOE-2-PyP5+ (BMX-001), have …

Significance: The nuclear factor erythroid 2-related factor 2 (NRF2)-Kelch-like ECH-
associated protein 1 (KEAP1) system is a master regulator of redox homeostasis and cell …

Abstract Mn (III) ortho-N-alkyl-and N-alkoxyalkyl porphyrins (MnPs) were initially developed
as superoxide dismutase (SOD) mimics. These compounds were later shown to react with …

Sickle cell disease (SCD) is an inherited monogenic disorder and the most common severe
hemoglobinopathy in the world. SCD is characterized by a point mutation in the β-globin …

Superoxide dismutases play an important role in human health and disease. Three decades
of effort have gone into synthesizing SOD mimics for clinical use. The result is the Mn …

Oxidative stress that results from an imbalance between the concentrations of reactive
species (RS) and antioxidant defenses is associated with many pathologies. Superoxide …

Significance: Persistent oxidative stress is a common feature of cancer cells, giving a
specific weapon to selectively eliminate them. Ascorbate in pharmacological concentration …