For decades metastatic squamous cell carcinoma of the anus (SCCA) has been considered
a rare disease with very limited treatment options and a dismal prognosis. Prior to 2017, no …

Simple Summary Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are a
group of tumors with different clinical manifestations, various localizations in the human …

BACKGROUND Gastric cancer (GC) is the sixth most common cancer and third leading
cause of cancer-related deaths worldwide. Current treatments mainly rely on surgery-and …

Simple Summary Store-operated Ca2+ entry (SOCE) has long been known to regulate the
differentiation and effector functions of T cells as well as to be instrumental to the ability of …

Microbiota consists of a dynamic organization of bacteria, viruses, archaea, and fungal
species involved in a number of vital functions spanning from the digestion of carbohydrates …

Methods We searched PubMed for articles related to ACT for CRC published as of August
31, 2022, and retrieved relevant clinical trial information on the National Institutes of Health …

Messenger RNA (mRNA) is being developed by researchers as a novel drug for the
treatment or prevention of many diseases. However, to enable mRNA to fully exploit its …

Cancer, a disease that modern medicine has not fully understood and conquered, with its
high incidence and mortality, deprives countless patients of health and even life. According …

Hepatocellular carcinoma (HCC) is considered a classic inflammation-associated tumor that
usually originates from chronic hepatitis, where an intense and chronic inflammatory …

T 细胞是获得性抗肿瘤免疫的重要细胞亚群, 但肿瘤组织中的T 细胞数量少, 且处于免疫抑制甚至
耗竭状态, 这是导致肿瘤免疫逃逸和免疫检查点抑制剂等抗肿瘤免疫治疗效果不佳的重要原因 …