Major perioperative cardiac events are estimated to complicate between 1.4% and 3.9% of
surgeries. Because most surgeries are elective, there is the opportunity to implement …

Protease-activated receptors (PARs) are a class of integral membrane proteins that are
cleaved by a variety of proteases, most notably thrombin, to reveal a tethered ligand and …

Objective Because the treatment of intermittent claudication (IC) is elective, good short-and
long-term outcomes are imperative. The objective of the present study was to examine the …

Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 receptor inhibitor is the
cornerstone of pharmacologic management of patients with acute coronary syndrome (ACS) …

In view of the rare presence of studies concerning platelet function as risk factor in
atherosclerotic patients, processes underlying thromboembolic events are reviewed in this …

Introduction: Despite the undeniable benefits on reducing ischemic adverse events,
antiplatelet regimens including dual antiplatelet therapy (DAPT) with aspirin and P2Y12 …

Background: Women may derive differential benefit from prolonged DAPT (dual antiplatelet
therapy) after coronary stenting than men. We assessed whether the risks/benefits of …

Whilst significant effort has been focused on development of tools and approaches to
clinically modulate activation processes that consume platelets, the platelet receptors that …

Background Sphingomyelin (SM) is an essential component of biological lipid rafts, and it
plays an indispensable role in maintaining plasma membrane stability and in mediating …

Dual antiplatelet therapy with clopidogrel is a regimen used before and after drug-eluting
stent (DES) implantation. Point-of-care platelet reactivity assays are easy-to-use methods to …