Most research on mechanisms of aging is being conducted in a very limited number of
classical model species, ie, laboratory mouse (Mus musculus), rat (Rattus norvegicus …

Aging is a nearly inescapable trait among organisms yet lifespan varies tremendously
across different species and spans several orders of magnitude in vertebrates alone. This …

The rates and patterns of somatic mutation in normal tissues are largely unknown outside of
humans,,,,,–. Comparative analyses can shed light on the diversity of mutagenesis across …

Comparative analysis of primate genomes within a phylogenetic context is essential for
understanding the evolution of human genetic architecture and primate diversity. We present …

Comparative genomics is the comparison of genetic information within and across
organisms to understand the evolution, structure, and function of genes, proteins, and non …

Evolving to become bigger and/or longer lived should increase cancer susceptibility, but this
predicted increase is not observed, a contradiction named Peto's paradox. A solution is that …

Although evolutionary biologists have long theorized that variation in DNA repair efficacy
might explain some of the diversity of lifespan and cancer incidence across species, we …

Cancer is pervasive across multicellular species, but what explains differences in cancer
prevalence across species? Using 16,049 necropsy records for 292 species spanning three …

Background Despite having been extensively studied, it remains largely unclear why
humans bear a particularly high risk of cancer. The antagonistic pleiotropy hypothesis …

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