Metalloproteinases (MPs) are proteolytic enzymes involved in extracellular matrix
deposition, regulation of cellular signals of inflammation, proliferation, and apoptosis …

Diabetic nephropathy is the most common cause of end-stage renal disease worldwide.
Control of blood glucose and blood pressure (BP) reduces the risk of developing this …

Chronic kidney disease (CKD) is a clinical condition characterized by high morbidity and
mortality. Globally, CKD is also increasing in prevalence and incidence. The two principal …

Chronic kidney disease (CKD) patients are characterized by a high residual risk for
cardiovascular (CV) events and CKD progression. This has prompted the implementation of …

Diabetes is the leading cause of kidney failure and specifically, diabetic kidney disease
(DKD) occurs in up to 30% of all diabetic patients. Kidney disease attributed to diabetes is a …

Anemia is a common complication of chronic kidney disease (CKD). The prevalence of
anemia in CKD strongly increases as the estimated Glomerular Filtration Rate (eGFR) …

ABSTRACT Introduction: Selective antagonists of Endothelin-1 receptors (ERA) have been
tested in diabetic and nondiabetic chronic kidney disease (CKD). The SONAR trial (Study Of …

Background Although chronic kidney disease (CKD) is associated with high multimorbidity,
polypharmacy, morbidity and mortality, existing classification systems (mild to severe …

Introduction Chronic kidney disease (CKD) is a disease which is spreading worldwide,
especially among older patients. Several prognostic scores have been developed to predict …

Background The colliding epidemic of infectious and non-communicable diseases in South
Africa could potentially increase the prevalence of kidney disease in the country. This study …