[HTML][HTML] Cancer stem cells—origins and biomarkers: perspectives for targeted personalized therapies

L Walcher, AK Kistenmacher, H Suo, R Kitte… - Frontiers in …, 2020 - frontiersin.org
The use of biomarkers in diagnosis, therapy and prognosis has gained increasing interest
over the last decades. In particular, the analysis of biomarkers in cancer patients within the …

[HTML][HTML] Breast cancer metastasis: mechanisms and therapeutic implications

M Park, D Kim, S Ko, A Kim, K Mo, H Yoon - International journal of …, 2022 - mdpi.com
Breast cancer is the most common malignancy in women worldwide. Metastasis is the
leading cause of high mortality in most cancers. Although predicting the early stage of breast …

[HTML][HTML] Spatial deconvolution of HER2-positive breast cancer delineates tumor-associated cell type interactions

A Andersson, L Larsson, L Stenbeck, F Salmén… - Nature …, 2021 - nature.com
In the past decades, transcriptomic studies have revolutionized cancer treatment and
diagnosis. However, tumor sequencing strategies typically result in loss of spatial …

Liposomes and extracellular vesicles as drug delivery systems: A comparison of composition, pharmacokinetics, and functionalization

L van der Koog, TB Gandek… - Advanced healthcare …, 2022 - Wiley Online Library
Over the past decades, lipid‐based nanoparticle drug delivery systems (DDS) have caught
the attention of researchers worldwide, encouraging the field to rapidly develop improved …

[HTML][HTML] Breast cancer treatments: updates and new challenges

A Burguin, C Diorio, F Durocher - Journal of personalized medicine, 2021 - mdpi.com
Breast cancer (BC) is the most frequent cancer diagnosed in women worldwide. This
heterogeneous disease can be classified into four molecular subtypes (luminal A, luminal B …

[HTML][HTML] Modular cytokine receptor-targeting chimeras for targeted degradation of cell surface and extracellular proteins

K Pance, JA Gramespacher, JR Byrnes… - Nature …, 2023 - nature.com
Targeted degradation of cell surface and extracellular proteins via lysosomal delivery is an
important means to modulate extracellular biology. However, these approaches have …

A trispecific antibody targeting HER2 and T cells inhibits breast cancer growth via CD4 cells

E Seung, Z Xing, L Wu, E Rao, V Cortez-Retamozo… - Nature, 2022 - nature.com
Effective antitumour immunity depends on the orchestration of potent T cell responses
against malignancies. Regression of human cancers has been induced by immune …

[HTML][HTML] Subtypes of breast cancer

E Orrantia-Borunda, P Anchondo-Nuñez… - Breast Cancer …, 2022 - ncbi.nlm.nih.gov
Breast cancer is a genetically and clinically heterogeneous disease with multiple subtypes.
The classification of these subtypes has evolved over the years. The most common and …

[HTML][HTML] Current state of breast cancer diagnosis, treatment, and theranostics

A Bhushan, A Gonsalves, JU Menon - Pharmaceutics, 2021 - mdpi.com
Breast cancer is one of the leading causes of cancer-related morbidity and mortality in
women worldwide. Early diagnosis and effective treatment of all types of cancers are crucial …

Delivery of CRISPR/Cas systems for cancer gene therapy and immunotherapy

X Song, C Liu, N Wang, H Huang, S He, C Gong… - Advanced drug delivery …, 2021 - Elsevier
The clustered, regularly interspaced, short palindromic repeats (CRISPR)/CRISPR-
associated protein (Cas) systems are efficient and versatile gene editing tools, which offer …