[HTML][HTML] Breast cancer cell line classification and its relevance with breast tumor subtyping
X Dai, H Cheng, Z Bai, J Li - Journal of Cancer, 2017 - ncbi.nlm.nih.gov
Breast cancer cell lines have been widely used for breast cancer modelling which
encompasses a panel of diseases with distinct phenotypical associations. Though cell lines …
encompasses a panel of diseases with distinct phenotypical associations. Though cell lines …
FBXW7: a critical tumor suppressor of human cancers
The ubiquitin-proteasome system (UPS) is involved in multiple aspects of cellular processes,
such as cell cycle progression, cellular differentiation, and survival (Davis RJ et al., Cancer …
such as cell cycle progression, cellular differentiation, and survival (Davis RJ et al., Cancer …
Human tumor-associated macrophage and monocyte transcriptional landscapes reveal cancer-specific reprogramming, biomarkers, and therapeutic targets
The roles of tumor-associated macrophages (TAMs) and circulating monocytes in human
cancer are poorly understood. Here, we show that monocyte subpopulation distribution and …
cancer are poorly understood. Here, we show that monocyte subpopulation distribution and …
Long noncoding RNA MALAT1 suppresses breast cancer metastasis
MALAT1 has previously been described as a metastasis-promoting long noncoding RNA
(lncRNA). We show here, however, that targeted inactivation of the Malat1 gene in a …
(lncRNA). We show here, however, that targeted inactivation of the Malat1 gene in a …
[HTML][HTML] A single-cell atlas of the tumor and immune ecosystem of human breast cancer
Breast cancer is a heterogeneous disease. Tumor cells and associated healthy cells form
ecosystems that determine disease progression and response to therapy. To characterize …
ecosystems that determine disease progression and response to therapy. To characterize …
Involvement of partial EMT in cancer progression
M Saitoh - The Journal of Biochemistry, 2018 - academic.oup.com
The epithelial–mesenchymal transition (EMT) provides an outstanding example of cellular
plasticity during embryonic development and cancer progression. During EMT in embryonic …
plasticity during embryonic development and cancer progression. During EMT in embryonic …
Cancer cell lines are useful model systems for medical research
P Mirabelli, L Coppola, M Salvatore - Cancers, 2019 - mdpi.com
Cell lines are in vitro model systems that are widely used in different fields of medical
research, especially basic cancer research and drug discovery. Their usefulness is primarily …
research, especially basic cancer research and drug discovery. Their usefulness is primarily …
MYC and MCL1 cooperatively promote chemotherapy-resistant breast cancer stem cells via regulation of mitochondrial oxidative phosphorylation
Most patients with advanced triple-negative breast cancer (TNBC) develop drug resistance.
MYC and MCL1 are frequently co-amplified in drug-resistant TNBC after neoadjuvant …
MYC and MCL1 are frequently co-amplified in drug-resistant TNBC after neoadjuvant …
Long-term culture, genetic manipulation and xenotransplantation of human normal and breast cancer organoids
JF Dekkers, EJ van Vliet, N Sachs, JM Rosenbluth… - Nature protocols, 2021 - nature.com
Organoid technology has revolutionized the study of human organ development, disease
and therapy response tailored to the individual. Although detailed protocols are available for …
and therapy response tailored to the individual. Although detailed protocols are available for …
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA
N 6-methyladenosine (m6A) modification of mRNA plays a role in regulating embryonic stem
cell pluripotency. However, the physiological signals that determine the balance between …
cell pluripotency. However, the physiological signals that determine the balance between …