Recent advances in the design and discovery of synthetic tyrosinase inhibitors

J Li, L Feng, L Liu, F Wang, L Ouyang, L Zhang… - European Journal of …, 2021 - Elsevier
Tyrosinase is a copper-containing metalloenzyme that is responsible for the rate-limiting
catalytic step in the melanin biosynthesis and enzymatic browning. As a promising target …

A systematic review of synthetic tyrosinase inhibitors and their structure-activity relationship

Z Peng, G Wang, QH Zeng, Y Li, H Liu… - Critical Reviews in …, 2022 - Taylor & Francis
Tyrosinase is a copper-containing oxidation enzyme, which is responsible for the production
of melanin. This enzyme is widely distributed in microorganisms, animals and plants, and …

Synthesis, Antimicrobial, Anti-Virulence and Anticancer Evaluation of New 5(4H)-Oxazolone-Based Sulfonamides

AJ Almalki, TS Ibrahim, ES Taher, MFA Mohamed… - Molecules, 2022 - mdpi.com
Since the synthesis of prontosil the first prodrug shares their chemical moiety, sulfonamides
exhibit diverse modes of actions to serve as antimicrobials, diuretics, antidiabetics, and other …

Synthesis, computational molecular docking analysis and effectiveness on tyrosinase inhibition of kojic acid derivatives

G Karakaya, A Türe, A Ercan, S Öncül, MD Aytemir - Bioorganic Chemistry, 2019 - Elsevier
Tyrosinase inhibitors have become increasingly important as whitening agents and for the
treatment of pigmentary disorders. In this study, the synthesis of kojic acid derivatives having …

A novel water soluble axially substituted silicon (IV) phthalocyanine bearing quaternized 4-(4-pyridinyl) phenol groups: Synthesis, characterization …

SY Al-Raqa, K Khezami, EN Kaya, M Durmuş - Polyhedron, 2021 - Elsevier
Abstract The novel axially bis [4-(4-pyridinyl) phenol] substituted silicon (IV) phthalocyanine
(3) and its quaternized derivative (3Q) were designed and synthesized. These …

Novel water soluble morpholine substituted Zn (II) phthalocyanine: Synthesis, characterization, DNA/BSA binding, DNA photocleavage and topoisomerase I inhibition

B Barut, Ü Demirbaş, A Özel, H Kantekin - International journal of biological …, 2017 - Elsevier
In this study, novel peripherally tetra 3-morpholinophenol substituted zinc (II) phthalocyanine
(4) and its water soluble form quaternized zinc (II) phthalocyanine (ZnQ) were synthesized …

[HTML][HTML] Novel oxazolones incorporated azo dye: Design, synthesis photophysical-DFT aspects and antimicrobial assessments with In-silico and In-vitro surveys

FF Albelwi, M Al-Anazi, A Naqvi, ZM Hritani… - … of Photochemistry and …, 2021 - Elsevier
New derivatives of the oxazolone compounds 4 (aj) and (7a-e) containing azo dye moieties
have been prepared via the Erlenmeyer reaction of their azo dye precursors. The …

The water soluble peripherally tetra-substituted zinc (II), manganese (III) and copper (II) phthalocyanines as new potential anticancer agents

B Barut, A Sofuoğlu, Z Biyiklioglu, A Özel - Dalton Transactions, 2016 - pubs.rsc.org
In this study,[2-(2-morpholin-4-ylethoxy) ethoxy] group substituted zinc (II), manganese (III)
and copper (II) phthalocyanines 2–4 and their water soluble derivatives 2a, 3a and 4a were …

Flow chemistry: towards a more sustainable heterocyclic synthesis

P Brandão, M Pineiro… - European Journal of …, 2019 - Wiley Online Library
Flow Chemistry is a revolutionary field in Organic Chemistry. By changing the conventional
methods and apparatus applied in the chemical synthesis, flow chemistry emerges as a …

Synthesis and characterization of metallophthalocyanine with morpholine containing Schiff base and determination of their antimicrobial and antioxidant activities

D Unluer, AA Kamiloglu, S Direkel, E Bektas… - Journal of …, 2019 - Elsevier
In this work, novel metallophthalocyanine compounds (M= Zn, Cu, Co) bearing four 2-
methoxy-4-{(Z)-[(4-morpholin-4-ylphenyl) imino] methyl} phenol at the peripheral positions …