D-dimer is a soluble fibrin degradation product that results from ordered breakdown of
thrombi by the fibrinolytic system. Numerous studies have shown that D-dimer serves as a …

Antiplatelet agents and anticoagulants are a mainstay for the prevention and treatment of
thrombosis. However, despite advances in antithrombotic therapy, a fundamental challenge …

Importance Venous thromboembolism (VTE), comprising deep vein thrombosis (DVT) and
pulmonary embolism (PE), is a common and potentially fatal disease. Objective To …

Objectives To determine the rate of a first recurrent venous thromboembolism (VTE) event
after discontinuation of anticoagulant treatment in patients with a first episode of unprovoked …

Venous thromboembolism (VTE) incidence increases sharply with age (Figure 1) and
appears steady over the last 25 years, despite preventive strategies. 1 Women are more …

Background: The long-term risk for major bleeding in patients receiving extended (beyond
the initial 3 to 6 months) anticoagulant therapy for a first unprovoked venous …

Background The efficacy and safety of direct oral anticoagulants (DOACs) for patients with
thrombotic antiphospholipid syndrome remain controversial. Objectives The authors …

Currently licenced direct oral anticoagulants selectively target thrombin (eg, dabigatran) or
coagulation factor Xa (eg, apixaban, betrixaban, edoxaban, and rivaroxaban). Designed to …

Abstract Severe Acute Respiratory Syndrome–Coronavirus-2 is responsible for the current
pandemic that has led to more than 10 million confirmed cases of Coronavirus Disease-19 …

Pulmonary embolism is a common and potentially fatal cardiovascular disorder that must be
promptly diagnosed and treated. The diagnosis, risk assessment, and management of …