or therapeutic medical strategies. However, the ESC Guidelines do not override in any way
whatsoever the individual responsibility of health professionals to make appropriate and …

Abstract Aim The “2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic
Disease” provides recommendations to guide clinicians in the diagnosis, genetic evaluation …

Mutations in fibrillin-1 cause Marfan syndrome (MFS), the most common heritable disorder of
connective tissue. Fibrillin-1 assemblies (microfibrils and elastic fibers) represent a unique …

Impairment of vascular function, in particular endothelial dysfunction and large elastic artery
stiffening, represents a major link between ageing and cardiovascular risk. Clinical and …

Introduction: Current guidelines recommend patients with thoracic aortic disease (TAD)
including inherited aortopathies to avoid heavy exercise. However, evidence supporting the …

Marfan syndrome (MFS) is a genetic disorder that frequently leads to aortic root dissection
and aneurysm. Despite promising preclinical and pilot clinical data, a recent large-scale …

Thoracic aortic dilatation is a progressive condition that results from aging and many
pathological conditions (ie, connective tissue, inflammatory, shear stress disorders, severe …

The involvement of highly reactive oxygen-derived free radicals (ROS) in the genesis and
progression of various cardiovascular diseases, including arrhythmias, aortic dilatation …

The association between physical activity and risk of abdominal aortic aneurysm has been
inconsistent with some studies reporting a reduced risk while others have found no …

Abstract In individuals with Marfan Syndrome (MFS), fibrillin-1 gene (FBN1) mutations can
lead to vascular wall weakening and dysfunction. The experimental mouse model of MFS …