[HTML][HTML] Assessing risks of Plasmodium falciparum resistance to select next-generation antimalarials

M Duffey, B Blasco, JN Burrows, TNC Wells… - Trends in …, 2021 - cell.com
Strategies to counteract or prevent emerging drug resistance are crucial for the design of
next-generation antimalarials. In the past, resistant parasites were generally identified …

Multi-omics approaches to improve malaria therapy

M Zhou, A Varol, T Efferth - Pharmacological Research, 2021 - Elsevier
Malaria contributes to the most widespread infectious diseases worldwide. Even though
current drugs are commercially available, the ever-increasing drug resistance problem by …

Current status of malaria chemotherapy and the role of pharmacology in antimalarial drug research and development

K Na‐Bangchang, J Karbwang - Fundamental & clinical …, 2009 - Wiley Online Library
Antimalarial drugs have played a mainstream role in controlling the spread of malaria
through the treatment of patients infected with the plasmodial parasites and controlling its …

[HTML][HTML] Hiding behind hydrophobicity: transmembrane segments in mass spectrometry

LA Eichacker, B Granvogl, O Mirus, BC Muller… - Journal of Biological …, 2004 - ASBMB
Proteomics of membrane proteins is essential for the understanding of cellular function.
However, mass spectrometric analysis of membrane proteomes has been less successful …

Proteomics of trypanosomatids of human medical importance

P Cuervo, GB Domont, JB De Jesus - Journal of Proteomics, 2010 - Elsevier
Leishmania spp., Trypanosoma cruzi, and Trypanosoma brucei are protozoan parasites that
cause a spectrum of fatal human diseases around the world. Recent completion of the …

[HTML][HTML] Drug development to protozoan diseases

L Monzote, A Siddiq - The Open Medicinal Chemistry Journal, 2011 - ncbi.nlm.nih.gov
The diseases caused by protozoan parasite are responsible for considerable mortality and
morbidity, affecting more than 500 million of people in the world. The epidemiological control …

[HTML][HTML] Plasmodium falciparum heat shock proteins as anti-malarial drug targets: An update

T Ahmad, BA Alhammadi, SY Almaazmi, S Arafa… - Cell Stress and …, 2024 - Elsevier
Global efforts to eradicate malaria are threatened by multiple factors, particularly the
emergence of anti-malarial drug resistant strains of Plasmodium falciparum. Heat shock …

Towards a proteomic definition of CoArtem action in Plasmodium falciparum malaria

M Makanga, PG Bray, P Horrocks, SA Ward - Proteomics, 2005 - Wiley Online Library
We have adopted a proteomic strategy to investigate the actions of the two active
components of the new antimalarial CoArtem, artemether and lumefantrine, following …

[HTML][HTML] Decrypting the complexity of the human malaria parasite biology through systems biology approaches

Z Chahine, KG Le Roch - Frontiers in systems biology, 2022 - frontiersin.org
The human malaria parasite, Plasmodium falciparum, is a unicellular protozoan responsible
for over half a million deaths annually. With a complex life cycle alternating between human …

Proteomic analyses of membrane enriched proteins of Leishmania donovani Indian clinical isolate by mass spectrometry

A Kumar, P Misra, B Sisodia, AK Shasany… - Parasitology …, 2015 - Elsevier
Visceral leishmaniasis (VL) is a major fatal disease prevalent in North-East India, caused by
a protozoan parasite Leishmania donovani. The parasite multiplies and thrives inside …