[HTML][HTML] Assessing risks of Plasmodium falciparum resistance to select next-generation antimalarials
M Duffey, B Blasco, JN Burrows, TNC Wells… - Trends in …, 2021 - cell.com
Strategies to counteract or prevent emerging drug resistance are crucial for the design of
next-generation antimalarials. In the past, resistant parasites were generally identified …
next-generation antimalarials. In the past, resistant parasites were generally identified …
Multi-omics approaches to improve malaria therapy
M Zhou, A Varol, T Efferth - Pharmacological Research, 2021 - Elsevier
Malaria contributes to the most widespread infectious diseases worldwide. Even though
current drugs are commercially available, the ever-increasing drug resistance problem by …
current drugs are commercially available, the ever-increasing drug resistance problem by …
Current status of malaria chemotherapy and the role of pharmacology in antimalarial drug research and development
K Na‐Bangchang, J Karbwang - Fundamental & clinical …, 2009 - Wiley Online Library
Antimalarial drugs have played a mainstream role in controlling the spread of malaria
through the treatment of patients infected with the plasmodial parasites and controlling its …
through the treatment of patients infected with the plasmodial parasites and controlling its …
[HTML][HTML] Hiding behind hydrophobicity: transmembrane segments in mass spectrometry
LA Eichacker, B Granvogl, O Mirus, BC Muller… - Journal of Biological …, 2004 - ASBMB
Proteomics of membrane proteins is essential for the understanding of cellular function.
However, mass spectrometric analysis of membrane proteomes has been less successful …
However, mass spectrometric analysis of membrane proteomes has been less successful …
Proteomics of trypanosomatids of human medical importance
Leishmania spp., Trypanosoma cruzi, and Trypanosoma brucei are protozoan parasites that
cause a spectrum of fatal human diseases around the world. Recent completion of the …
cause a spectrum of fatal human diseases around the world. Recent completion of the …
[HTML][HTML] Drug development to protozoan diseases
The diseases caused by protozoan parasite are responsible for considerable mortality and
morbidity, affecting more than 500 million of people in the world. The epidemiological control …
morbidity, affecting more than 500 million of people in the world. The epidemiological control …
[HTML][HTML] Plasmodium falciparum heat shock proteins as anti-malarial drug targets: An update
T Ahmad, BA Alhammadi, SY Almaazmi, S Arafa… - Cell Stress and …, 2024 - Elsevier
Global efforts to eradicate malaria are threatened by multiple factors, particularly the
emergence of anti-malarial drug resistant strains of Plasmodium falciparum. Heat shock …
emergence of anti-malarial drug resistant strains of Plasmodium falciparum. Heat shock …
Towards a proteomic definition of CoArtem action in Plasmodium falciparum malaria
M Makanga, PG Bray, P Horrocks, SA Ward - Proteomics, 2005 - Wiley Online Library
We have adopted a proteomic strategy to investigate the actions of the two active
components of the new antimalarial CoArtem, artemether and lumefantrine, following …
components of the new antimalarial CoArtem, artemether and lumefantrine, following …
[HTML][HTML] Decrypting the complexity of the human malaria parasite biology through systems biology approaches
Z Chahine, KG Le Roch - Frontiers in systems biology, 2022 - frontiersin.org
The human malaria parasite, Plasmodium falciparum, is a unicellular protozoan responsible
for over half a million deaths annually. With a complex life cycle alternating between human …
for over half a million deaths annually. With a complex life cycle alternating between human …
Proteomic analyses of membrane enriched proteins of Leishmania donovani Indian clinical isolate by mass spectrometry
Visceral leishmaniasis (VL) is a major fatal disease prevalent in North-East India, caused by
a protozoan parasite Leishmania donovani. The parasite multiplies and thrives inside …
a protozoan parasite Leishmania donovani. The parasite multiplies and thrives inside …