Abnormal shifts in the composition of gut microbiota contribute to the pathogenesis of
metabolic diseases, including obesity and type 2 diabetes (T2DM). The crosstalk between …

Human genetics is now at a critical juncture. The molecular methods used successfully to
identify the genes underlying rare mendelian syndromes are failing to find the numerous …

Genetic contributions to the cause of type 1 diabetes have been studied for more than 30
years, but only recently, with modern genetic tools, has the importance of seemingly minor …

Wolcott-Rallison syndrome (WRS) is a rare, autosomal recessive disorder characterized by
permanent neonatal or early infancy insulin-dependent diabetes. Epiphyseal dysplasia …

Abstract Wolfram syndrome (WFS; OMIM 222300) is an autosomal recessive
neurodegenerative disorder defined by young-onset non-immune insulin-dependent …

Type 2 or non-insulin-dependent diabetes mellitus (NIDDM) is the most common form of
diabetes worldwide, affecting approximately 4% of the world's adult population. It is …

BACKGROUND Type 1 diabetes, a multifactorial disease with a strong genetic component,
is caused by the autoimmune destruction of pancreatic β cells. The major susceptibility locus …

The predisposition of individuals to several common autoimmune diseases, such as
rheumatoid arthritis, systemic lupus erythematosus and multiple sclerosis, is genetically …

Type 1 diabetes results from the autoimmune destruction of insulin-producing β cells in the
pancreas. Genetic and, as yet undefined, environmental factors act together to precipitate …

Abstract “If it were not for the great variability among individuals medicine might as well be a
science and not an art.” The thoughts of Sir William Osler in 1892 reflect the view of …