In the realm of gene therapy, a pivotal moment arrived with Paul Berg's groundbreaking
identification of the first recombinant DNA in 1972. This achievement set the stage for future …

The recent success of gene therapy during the COVID‐19 pandemic has underscored the
importance of effective and safe delivery systems. Complementing lipid‐based delivery …

Nucleic acid-based medicines and vaccines are becoming an important part of our
therapeutic toolbox. One key genetic medicine is antisense oligonucleotides (ASOs), which …

Antisense oligonucleotides (ASOs) are an important emerging therapeutic; however, they
struggle to enter cells without a delivery vehicle, such as a cationic polymer. To understand …

Herein, we examine the ASO-mediated gene silencing efficiency of pH-responsive micelles,
by incorporating 2-(diisopropylamino) ethyl methacrylate (DIP) into the micelle core and …

Broad size distributions and poor long‐term colloidal stability of microRNA‐carrying
nanoparticles, especially those formed by polyelectrolyte complexation, represent major …

The bacterial cell envelope provides a protective barrier that is challenging for small
molecules and biomolecules to cross. Given the anionic nature of both Gram-positive and …

Prostate cancer (PCa) is the most frequent cancer among men throughout the world. The
available conventional therapies such as androgen deprivation therapy and surgical …

Microspheres bearing large pores are useful in the capture and separation of biomolecules.
However, pore size is typically poorly controlled, leading to disordered porous structures …