Background Many depressed patients are not able to achieve or sustain symptom remission
despite serial treatment trials–often termed “treatment resistant depression”. A broader …

Background Suicidal ideation (SI) and suicide planning (SP) are associated with an
increased risk of future suicide. We performed a meta-analysis of observational studies to …

Background Patients with major depressive disorder (MDD) having active suicidal ideation
with intent require immediate treatment. Methods This double-blind study (ASPIRE II) …

Patients with treatment-resistant depression (TRD) have higher rates of relapse and
pronounced decreases in daily functioning and health-related quality of life compared to …

Objectives: The overview outlines two decades of research from the European Group for the
Study of Resistant Depression (GSRD) that fundamentally impacted evidence-based …

Objective: Suicide is a global health concern, and innovative interventions that target
suicidality are needed. While psychedelic therapy shows promise for a range of mental …

Approximately one-third of patients with major depressive disorder (MDD) have treatment-
resistant depression (TRD). The TRAL study will evaluate the prevalence and impact of TRD …

Background Individuals with major depressive disorder (MDD) are at higher risk for obesity.
In turn, weight gain is a predisposing factor for depression. Although clinical data are sparse …

Background Treatment-resistant depression (TRD) may represent a substantial proportion of
major depressive disorder (MDD); however, the risk of mortality in TRD is still incompletely …

Thyroid dysfunction is common in major depressive disorder (MDD) patients; however, its
relationship with psychotic depression (PD) remains unclear. We aimed to assess thyroid …