Atopic dermatitis: an expanding therapeutic pipeline for a complex disease
T Bieber - Nature reviews Drug discovery, 2022 - nature.com
Atopic dermatitis (AD) is a common chronic inflammatory skin disease with a complex
pathophysiology that underlies a wide spectrum of clinical phenotypes. AD remains …
pathophysiology that underlies a wide spectrum of clinical phenotypes. AD remains …
[HTML][HTML] Biomarkers in atopic dermatitis—a review on behalf of the International Eczema Council
Y Renert-Yuval, JP Thyssen, R Bissonnette… - Journal of Allergy and …, 2021 - Elsevier
Atopic dermatitis (AD) is a common yet complex skin disease, posing a therapeutic
challenge with increasingly recognized different phenotypes among variable patient …
challenge with increasingly recognized different phenotypes among variable patient …
An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging
While many diseases of aging have been linked to the immunological system, immune
metrics capable of identifying the most at-risk individuals are lacking. From the blood …
metrics capable of identifying the most at-risk individuals are lacking. From the blood …
Update on the pathogenesis and therapy of atopic dermatitis
H Li, Z Zhang, H Zhang, Y Guo, Z Yao - Clinical reviews in allergy & …, 2021 - Springer
Atopic dermatitis (AD) is a common inflammatory skin disorder characterized by recurrent
eczematous lesions and intense itch. Although it most often starts in infancy and affects …
eczematous lesions and intense itch. Although it most often starts in infancy and affects …
Interleukin‐13: targeting an underestimated cytokine in atopic dermatitis
T Bieber - Allergy, 2020 - Wiley Online Library
Atopic dermatitis (AD) is a common inflammatory skin condition that has traditionally been
considered a paradigmatic type 2 immunity (T2)‐driven disease. Interleukin (IL)‐4 and IL‐13 …
considered a paradigmatic type 2 immunity (T2)‐driven disease. Interleukin (IL)‐4 and IL‐13 …
Efficacy and safety of lebrikizumab, a high-affinity interleukin 13 inhibitor, in adults with moderate to severe atopic dermatitis: a phase 2b randomized clinical trial
Importance Interleukin 13 (IL-13) is a central pathogenic mediator driving multiple features of
atopic dermatitis (AD) pathophysiology. Objective To evaluate the efficacy and safety of …
atopic dermatitis (AD) pathophysiology. Objective To evaluate the efficacy and safety of …
Disease modification in inflammatory skin disorders: opportunities and challenges
T Bieber - Nature Reviews Drug Discovery, 2023 - nature.com
Progress in understanding of the mechanisms underlying chronic inflammatory skin
disorders, such as atopic dermatitis and psoriasis vulgaris, has led to new treatment options …
disorders, such as atopic dermatitis and psoriasis vulgaris, has led to new treatment options …
The molecular features of normal and atopic dermatitis skin in infants, children, adolescents, and adults
Y Renert-Yuval, E Del Duca, AB Pavel, M Fang… - Journal of Allergy and …, 2021 - Elsevier
Background Although atopic dermatitis (AD) often presents in infancy and persists into
adulthood, comparative characterization of AD skin among different pediatric age groups is …
adulthood, comparative characterization of AD skin among different pediatric age groups is …
Multiple roles for cytokines in atopic dermatitis: from pathogenic mediators to endotype-specific biomarkers to therapeutic targets
Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases, which
generally presents with intense itching and recurrent eczematous lesions. AD affects up to …
generally presents with intense itching and recurrent eczematous lesions. AD affects up to …
The proteomic skin profile of moderate-to-severe atopic dermatitis patients shows an inflammatory signature
Background Moderate-to-severe atopic dermatitis (AD) is increasingly recognized as a
systemic disease, largely due to proteomic blood studies. There are growing efforts to …
systemic disease, largely due to proteomic blood studies. There are growing efforts to …