Colorectal cancer: current updates and future perspectives

R Marcellinaro, D Spoletini, M Grieco, P Avella… - Journal of Clinical …, 2023 - mdpi.com
Colorectal cancer is a frequent neoplasm in western countries, mainly due to dietary and
behavioral factors. Its incidence is growing in developing countries for the westernization of …

[HTML][HTML] Roles and mechanisms of miR-195–5p in human solid cancers

Q Xu, JL Xu, WQ Chen, WX Xu, YX Song… - Biomedicine & …, 2022 - Elsevier
Cancer persists as a worldwide disease that contributes to high morbidity and mortality
rates. As a class of non-coding RNA, microRNAs (miRNAs) are one kind of important …

Fluoroindole chalcone analogues targeting the colchicine binding site of tubulin for colorectal oncotherapy

X Liu, J Jin, Y Wu, B Du, L Zhang, D Lu, Y Liu… - European Journal of …, 2023 - Elsevier
Colorectal cancer (CRC) is a common malignancy of the gastrointestinal tract with high
morbidity and mortality. Our previous studies have demonstrated that indole-chalcone …

Cordycepin remodels the tumor microenvironment of colorectal cancer by down-regulating the expression of PD-L1

S Wu, W Fang, L Chen, C Feng, R Chen, H Ying… - Journal of Cancer …, 2023 - Springer
Purpose Colorectal cancer, as a common malignant tumor, poses a serious threat to human
life. Cordycepin, derived from Cordyceps militari s extract, which was established as a …

[HTML][HTML] Integrative bioinformatics analysis of ACS enzymes as candidate prognostic and diagnostic biomarkers in colon adenocarcinoma

E Parsazad, F Esrafili, B Yazdani… - Research in …, 2023 - journals.lww.com
Background and purpose: Acyl-CoA synthetase (ACS) enzymes play an important role in the
activation of fatty acids. While many studies have found correlations between the expression …

Stage-dependent levels of brain-derived neurotrophic factor and matrix metalloproteinase 9 in the prognosis of colorectal cancer

I Večurkovská, J Mašlanková, V Tomečková… - Biomedicines, 2023 - mdpi.com
Simple Summary The ever-increasing number of CRC cases and the associated number of
deaths from this type of cancer require the development of sensitive, accurate, and non …

EMR1/ADGRE1 expression in cancer cells upregulated by tumor-associated macrophages is related to poor prognosis in colorectal cancer

R Akter, K Kim, HY Kwon, Y Kim, YW Eom, H Cho… - Biomedicines, 2022 - mdpi.com
EMR1, a member of the adhesion G protein-coupled receptor family (ADGRE1), is a
macrophage marker that is abnormally expressed in cancer cells. However, its clinical …

[HTML][HTML] N6-methyladenosine-dependent signaling in colorectal cancer: functions and clinical potential

S Liu, M Liu, Y Li, Q Song - Critical Reviews in Oncology/Hematology, 2024 - Elsevier
Colorectal cancer (CRC) ranks as the third most prevalent malignancy worldwide. Despite
the gradual expansion of therapeutic options for CRC, its clinical management remains a …

Synthesis and Cytotoxic Activity of 1,2,4-Triazolo-Linked Bis-Indolyl Conjugates as Dual Inhibitors of Tankyrase and PI3K

PA Yakkala, SR Panda, S Shafi, VGM Naidu, MS Yar… - Molecules, 2022 - mdpi.com
A series of new 1, 2, 4-triazolo-linked bis-indolyl conjugates (15a–r) were prepared by
multistep synthesis and evaluated for their cytotoxic activity against various human cancer …

Upregulation of EMR1 (ADGRE1) by Tumor-Associated Macrophages Promotes Colon Cancer Progression by Activating the JAK2/STAT1, 3 Signaling Pathway in …

R Akter, R Park, SK Lee, E Han, KS Park… - International journal of …, 2024 - mdpi.com
Previously, we reported that epidermal growth factor-like module-containing mucin-like
hormone receptor-like 1 (EMR1/ADGRE1) is abnormally expressed in colon cancer (CC) …