Emerging evidence that the mammalian sperm epigenome serves as a template for embryo development
Although more studies are demonstrating that a father's environment can influence child
health and disease, the molecular mechanisms underlying non-genetic inheritance remain …
health and disease, the molecular mechanisms underlying non-genetic inheritance remain …
[HTML][HTML] Lifestyle interventions to reduce endocrine-disrupting phthalate and phenol exposures among reproductive age men and women: A review and future steps
Non-persistent endocrine-disrupting chemicals (EDCs), including phthalates and phenols,
are ubiquitous in both the environment and human body. A growing body of epidemiologic …
are ubiquitous in both the environment and human body. A growing body of epidemiologic …
[HTML][HTML] Paternal phthalate exposure-elicited offspring metabolic disorders are associated with altered sperm small RNAs in mice
Exposure to ubiquitous plastic-associated endocrine disrupting chemicals (EDCs) is
associated with the increased risk of many chronic diseases. For example, phthalate …
associated with the increased risk of many chronic diseases. For example, phthalate …
Impact of endocrine disruptors upon non-genetic inheritance
D Montjean, AS Neyroud, MG Yefimova… - International Journal of …, 2022 - mdpi.com
Similar to environmental factors, EDCs (endocrine-disrupting chemicals) can influence gene
expression without modifying the DNA sequence. It is commonly accepted that the …
expression without modifying the DNA sequence. It is commonly accepted that the …
Di-2-ethylhexyl phthalate (DEHP) exposure induces sperm quality and functional defects in mice
L XueXia, L YaNan, T Zi, Z YuSheng, W ZeLin, Z Peng… - Chemosphere, 2023 - Elsevier
Abstract Di-2-ethylhexyl phthalate (DEHP) harms mammalian testis development, yet the
specific mechanism of its effect on sperm quality and function is unclear. In this study, male …
specific mechanism of its effect on sperm quality and function is unclear. In this study, male …
[HTML][HTML] Mixtures of per-and polyfluoroalkyl substances (PFAS) alter sperm methylation and long-term reprogramming of offspring liver and fat transcriptome
DAL Maxwell, OA Oluwayiose, E Houle, K Roth… - Environment …, 2024 - Elsevier
Male fertility has been declining worldwide especially in countries with high levels of
endocrine disrupting chemicals (EDCs). Per-and polyfluorinated alkyl Substances (PFAS) …
endocrine disrupting chemicals (EDCs). Per-and polyfluorinated alkyl Substances (PFAS) …
Microplastics exposure: implications for human fertility, pregnancy and child health
Plastics found in our everyday environment are becoming an increasing concern for
individual and population-level health, and the extent of exposure and potential toxic effects …
individual and population-level health, and the extent of exposure and potential toxic effects …
The association between long-term DDT or DDE exposures and an altered sperm epigenome—a cross-sectional study of Greenlandic Inuit and South African …
Background: The organochlorine dichlorodiphenyltrichloroethane (DDT) is banned
worldwide owing to its negative health effects. It is exceptionally used as an insecticide for …
worldwide owing to its negative health effects. It is exceptionally used as an insecticide for …
Urinary phthalate metabolites and their mixtures are associated with advanced sperm epigenetic aging in a general population
Introduction We have recently shown that sperm epigenetic age (SEA), a surrogate measure
of biological aging in sperm, is associated with couples' time-to-pregnancy (TTP). Advanced …
of biological aging in sperm, is associated with couples' time-to-pregnancy (TTP). Advanced …
Association of phthalate exposure with reproductive outcomes among infertile couples undergoing in vitro fertilization: A systematic review
T Xiangming, Q Boyi, Y Li, L Huanhuan, W Zhou - Environmental Research, 2024 - Elsevier
Human fertility is impacted by changes in lifestyle and environmental deterioration. To
increase human fertility, assisted reproductive technology (ART) has been extensively used …
increase human fertility, assisted reproductive technology (ART) has been extensively used …