[HTML][HTML] How the immune system shapes atherosclerosis: roles of innate and adaptive immunity

P Roy, M Orecchioni, K Ley - Nature Reviews Immunology, 2022 - nature.com
Atherosclerosis is the root cause of many cardiovascular diseases. Extensive research in
preclinical models and emerging evidence in humans have established the crucial roles of …

[HTML][HTML] T cell subsets and functions in atherosclerosis

R Saigusa, H Winkels, K Ley - Nature Reviews Cardiology, 2020 - nature.com
Atherosclerosis is a chronic inflammatory disease of the arterial wall and the primary
underlying cause of cardiovascular disease. Data from in vivo imaging, cell-lineage tracing …

Regulatory T-cell and neutrophil extracellular trap interaction contributes to carcinogenesis in non-alcoholic steatohepatitis

H Wang, H Zhang, Y Wang, ZJ Brown, Y Xia… - Journal of …, 2021 - Elsevier
Background & Aims Regulatory T-cells (Tregs) impair cancer immunosurveillance by
creating an immunosuppressive environment that fosters tumor cell survival. Our previous …

Propionate attenuates atherosclerosis by immune-dependent regulation of intestinal cholesterol metabolism

A Haghikia, F Zimmermann, P Schumann… - European Heart …, 2022 - academic.oup.com
Aims Atherosclerotic cardiovascular disease (ACVD) is a major cause of mortality and
morbidity worldwide, and increased low-density lipoproteins (LDLs) play a critical role in …

Immunity and inflammation in atherosclerosis

D Wolf, K Ley - Circulation research, 2019 - Am Heart Assoc
There is now overwhelming experimental and clinical evidence that atherosclerosis is a
chronic inflammatory disease. Lessons from genome-wide association studies, advanced in …

Meta-analysis of leukocyte diversity in atherosclerotic mouse aortas

A Zernecke, H Winkels, C Cochain… - Circulation …, 2020 - Am Heart Assoc
The diverse leukocyte infiltrate in atherosclerotic mouse aortas was recently analyzed in 9
single-cell RNA sequencing and 2 mass cytometry studies. In a comprehensive meta …

[HTML][HTML] The immunology of atherosclerosis

A Gisterå, GK Hansson - Nature reviews nephrology, 2017 - nature.com
Cardiovascular disease is the leading cause of death worldwide, both in the general
population and among patients with chronic kidney disease (CKD). In most cases, the …

Regulatory T cells license macrophage pro-resolving functions during atherosclerosis regression

M Sharma, MP Schlegel, MS Afonso, EJ Brown… - Circulation …, 2020 - Am Heart Assoc
Rationale: Regression of atherosclerosis is an important clinical goal; however, the
pathways that mediate the resolution of atherosclerotic inflammation and reversal of plaques …

Inflammation and plaque vulnerability

GK Hansson, P Libby, I Tabas - Journal of internal medicine, 2015 - Wiley Online Library
Atherosclerosis is a maladaptive, nonresolving chronic inflammatory disease that occurs at
sites of blood flow disturbance. The disease usually remains silent until a breakdown of …

Mechanisms of immune regulation in allergic diseases: the role of regulatory T and B cells

O Palomares, M Akdis, M Martín‐Fontecha… - Immunological …, 2017 - Wiley Online Library
Allergy is a major public health problem with a high socio‐economic impact. The number of
allergic patients is expected to reach to four billion within two decades when the World's …