Carbohydrate-based macromolecular biomaterials
Carbohydrates are the most abundant and one of the most important biomacromolecules in
Nature. Except for energy-related compounds, carbohydrates can be roughly divided into …
Nature. Except for energy-related compounds, carbohydrates can be roughly divided into …
Sialic acids in cancer biology and immunity
OMT Pearce, H Läubli - Glycobiology, 2016 - academic.oup.com
During malignant transformation, glycosylation is heavily altered compared with healthy
tissue due to differential expression of glycosyltransferases, glycosidases and …
tissue due to differential expression of glycosyltransferases, glycosidases and …
The sweet and sour of cancer: glycans as novel therapeutic targets
A growing body of evidence supports crucial roles for glycans at various pathophysiological
steps of tumour progression. Glycans regulate tumour proliferation, invasion …
steps of tumour progression. Glycans regulate tumour proliferation, invasion …
The role of antibody responses against glycans in bioprosthetic heart valve calcification and deterioration
T Senage, A Paul, T Le Tourneau, I Fellah-Hebia… - Nature medicine, 2022 - nature.com
Bioprosthetic heart valves (BHVs) are commonly used to replace severely diseased heart
valves but their susceptibility to structural valve degeneration (SVD) limits their use in young …
valves but their susceptibility to structural valve degeneration (SVD) limits their use in young …
Mucin O-glycans are natural inhibitors of Candida albicans pathogenicity
Mucins are large gel-forming polymers inside the mucus barrier that inhibit the yeast-to-
hyphal transition of Candida albicans, a key virulence trait of this important human fungal …
hyphal transition of Candida albicans, a key virulence trait of this important human fungal …
Targeting sialic acid–Siglec interactions to reverse immune suppression in cancer
OJ Adams, MA Stanczak, S von Gunten, H Läubli - Glycobiology, 2018 - academic.oup.com
Abstract Changes in sialic acids in cancer have been observed for many years. In particular,
the increase of sialoglycan density or hypersialylation in tumors has been described. Recent …
the increase of sialoglycan density or hypersialylation in tumors has been described. Recent …
B4GALNT2 and xenotransplantation: a newly appreciated xenogeneic antigen
G Byrne, S Ahmad‐Villiers, Z Du… - …, 2018 - Wiley Online Library
Abstract Analysis of non‐Gal antibody induced after pig‐to‐baboon cardiac
xenotransplantation identified the glycan produced by porcine beta‐1, 4‐N‐acetyl …
xenotransplantation identified the glycan produced by porcine beta‐1, 4‐N‐acetyl …
Stable gold-nanoparticle-based vaccine for the targeted delivery of tumor-associated glycopeptide antigens
KR Trabbic, KA Kleski, JJ Barchi Jr - ACS bio & med chem Au, 2021 - ACS Publications
We have developed a novel antigen delivery system based on polysaccharide-coated gold
nanoparticles (AuNPs) targeted to antigen-presenting cells (APCs) expressing Dectin-1 …
nanoparticles (AuNPs) targeted to antigen-presenting cells (APCs) expressing Dectin-1 …
The effects of allicin, a reactive sulfur species from garlic, on a selection of mammalian cell lines
MCH Gruhlke, C Nicco, F Batteux, AJ Slusarenko - Antioxidants, 2016 - mdpi.com
Garlic (Allium sativum L.) has been used as a spice and medicinal plant since ancient times.
Garlic produces the thiol-reactive defence substance, allicin, upon wounding. The effects of …
Garlic produces the thiol-reactive defence substance, allicin, upon wounding. The effects of …
Recent advances on smart glycoconjugate vaccines in infections and cancer
M Anderluh, F Berti, A Bzducha‐Wróbel… - The FEBS …, 2022 - Wiley Online Library
Vaccination is one of the greatest achievements in biomedical research preventing death
and morbidity in many infectious diseases through the induction of pathogen‐specific …
and morbidity in many infectious diseases through the induction of pathogen‐specific …