Carbohydrate-based macromolecular biomaterials

L Su, Y Feng, K Wei, X Xu, R Liu, G Chen - Chemical Reviews, 2021 - ACS Publications
Carbohydrates are the most abundant and one of the most important biomacromolecules in
Nature. Except for energy-related compounds, carbohydrates can be roughly divided into …

Sialic acids in cancer biology and immunity

OMT Pearce, H Läubli - Glycobiology, 2016 - academic.oup.com
During malignant transformation, glycosylation is heavily altered compared with healthy
tissue due to differential expression of glycosyltransferases, glycosidases and …

The sweet and sour of cancer: glycans as novel therapeutic targets

MM Fuster, JD Esko - Nature Reviews Cancer, 2005 - nature.com
A growing body of evidence supports crucial roles for glycans at various pathophysiological
steps of tumour progression. Glycans regulate tumour proliferation, invasion …

The role of antibody responses against glycans in bioprosthetic heart valve calcification and deterioration

T Senage, A Paul, T Le Tourneau, I Fellah-Hebia… - Nature medicine, 2022 - nature.com
Bioprosthetic heart valves (BHVs) are commonly used to replace severely diseased heart
valves but their susceptibility to structural valve degeneration (SVD) limits their use in young …

Mucin O-glycans are natural inhibitors of Candida albicans pathogenicity

J Takagi, K Aoki, BS Turner, S Lamont… - Nature chemical …, 2022 - nature.com
Mucins are large gel-forming polymers inside the mucus barrier that inhibit the yeast-to-
hyphal transition of Candida albicans, a key virulence trait of this important human fungal …

Targeting sialic acid–Siglec interactions to reverse immune suppression in cancer

OJ Adams, MA Stanczak, S von Gunten, H Läubli - Glycobiology, 2018 - academic.oup.com
Abstract Changes in sialic acids in cancer have been observed for many years. In particular,
the increase of sialoglycan density or hypersialylation in tumors has been described. Recent …

B4GALNT2 and xenotransplantation: a newly appreciated xenogeneic antigen

G Byrne, S Ahmad‐Villiers, Z Du… - …, 2018 - Wiley Online Library
Abstract Analysis of non‐Gal antibody induced after pig‐to‐baboon cardiac
xenotransplantation identified the glycan produced by porcine beta‐1, 4‐N‐acetyl …

Stable gold-nanoparticle-based vaccine for the targeted delivery of tumor-associated glycopeptide antigens

KR Trabbic, KA Kleski, JJ Barchi Jr - ACS bio & med chem Au, 2021 - ACS Publications
We have developed a novel antigen delivery system based on polysaccharide-coated gold
nanoparticles (AuNPs) targeted to antigen-presenting cells (APCs) expressing Dectin-1 …

The effects of allicin, a reactive sulfur species from garlic, on a selection of mammalian cell lines

MCH Gruhlke, C Nicco, F Batteux, AJ Slusarenko - Antioxidants, 2016 - mdpi.com
Garlic (Allium sativum L.) has been used as a spice and medicinal plant since ancient times.
Garlic produces the thiol-reactive defence substance, allicin, upon wounding. The effects of …

Recent advances on smart glycoconjugate vaccines in infections and cancer

M Anderluh, F Berti, A Bzducha‐Wróbel… - The FEBS …, 2022 - Wiley Online Library
Vaccination is one of the greatest achievements in biomedical research preventing death
and morbidity in many infectious diseases through the induction of pathogen‐specific …