The field of metabolic engineering is primarily concerned with improving the biological
production of value-added chemicals, fuels and pharmaceuticals through the design …

Studying cell metabolism serves a plethora of objectives such as the enhancement of
bioprocess performance, and advancement in the understanding of cell biology, of drug …

Through advanced mechanistic modeling and the generation of large high-quality datasets,
machine learning is becoming an integral part of understanding and engineering living …

Highlights•New predictive modeling approaches and better tools to manipulate microbiome
interactions are needed.•Identifying and validating cross–feeding interactions in microbial …

Highlights•Kinetic models integrate heterogeneous data to give metabolic engineering
insights.•Need accurate catalytic and allostery kinetic parameters for quality kinetic …

Overflow metabolism refers to the production of seemingly wasteful by-products by cells
during growth on glucose even when oxygen is abundant. Two theories have been …

In the era of sustainable development, the use of cell factories to produce various
compounds by fermentation has attracted extensive attention; however, industrial …

Protein serine/threonine/tyrosine (S/T/Y) phosphorylation is an essential and frequent post-
translational modification in eukaryotes, but historically has been considered less prevalent …

Metabolic flux analysis (MFA) quantitatively describes cellular fluxes to understand
metabolic phenotypes and functional behaviour after environmental and/or genetic …

As an important raw material for pharmaceutical, food and feed industry, highly efficient
production of L-tryptophan by Escherichia coli has attracted a considerable attention …